SCHEMBL21296847

SCHEMBL21296847

COc1ccc(-c2ccc(Oc3[nH]nnc3C(=O)O)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKAG1 P54619 2/20 0.51
PRKAA1 Q13131 2/20 0.51
PRKAB1 Q9Y478 2/20 0.51
HAO1 Q9UJM8 2/20 0.49
ALPL P05186 2/20 0.49
CA9 Q16790 1/20 0.49
PRKAB2 O43741 1/20 0.43
PRKAA2 P54646 1/20 0.43
PRKAG3 Q9UGI9 1/20 0.43
PRKAG2 Q9UGJ0 1/20 0.43
MCL1 Q07820 1/20 0.43
MAPT P10636 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
NPC1 O15118 2/20 0.42
LMNA P02545 2/20 0.42
RAB9A P51151 2/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21296956 0.96 HAO1 (0.52) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21296952 0.92 RXRA (0.51) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21296929 0.89 PIN1 (0.49) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL29799086 0.89 PRKAG1 (0.50) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21296954 0.89 PRKAG1 (0.50) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21296970 0.89 ALPL (0.42) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL21296854 0.88 HAO1 (0.44) PRKAG1PRKAA1PRKAB1HAO1MCL1
SCHEMBL23001821 0.88 HAO1 (0.65) HAO1
SCHEMBL21296848 0.87 PRKAG1 (0.45) PRKAG1PRKAA1PRKAB1HAO1ALPL
SCHEMBL23319968 0.86 HAO1 (0.50) PRKAG1PRKAA1PRKAB1HAO1ALPL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 US disclosed
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 US disclosed
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS PHOENIX TISSUE REPAIR, INC. 2023-05-11 US disclosed
US-11389456-B2 Compounds and methods for treating oxalate-related diseases OXALURX, INC. (US) 2022-07-19 US disclosed
US-20210403439-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS VENTHERA, INC. 2021-12-30 US disclosed
EP-3817816-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS Orfan Biotech Inc. (US) 2021-05-12 EP disclosed
US-20200390778-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES OXALURX, INC. 2020-12-17 US disclosed
US-20200390778-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES OXALURX, INC. 2020-12-17 US disclosed
WO-2019165159-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES OXALURX, INC. (US) 2019-08-29 WO disclosed
WO-2019165159-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES OXALURX, INC. (US) 2019-08-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230143491-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO PRKAG1 2945/4885PRKAA1 2067/4885PRKAB1 3254/4885
US-20200390778-A1 COMPOUNDS AND METHODS FOR TREATING OXALATE-RELATED DISEASES XDH, PNPO, LOX PRKAG1 2580/4885PRKAA1 2860/4885PRKAB1 2716/4885
US-11389456-B2 Compounds and methods for treating oxalate-related diseases XDH, PNPO, LOX PRKAG1 2580/4885PRKAA1 2860/4885PRKAB1 2716/4885
US-20210403439-A1 TRIAZOLE GLYCOLATE OXIDASE INHIBITORS XDH, DUOX1, PNPO PRKAG1 2945/4885PRKAA1 2067/4885PRKAB1 3254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.