Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23426162 | 0.79 | LTA4H (0.40) | ALDH1A1KDM4EHPGDTSHRMAPK1 | |
| SCHEMBL19355326 | 0.75 | NPBWR1 (0.42) | TYRO3KITLTA4HL3MBTL1PDE5A | |
| SCHEMBL15342931 | 0.75 | PKM (0.50) | SMN1; SMN2GAAMAPK1LTA4HKDR | |
| SCHEMBL23426122 | 0.74 | SAE1 (0.41) | MCHR1SMN1; SMN2TSHRMAPK1MAPT | |
| SCHEMBL18329684 | 0.71 | NPC1 (0.44) | MCHR1SMN1; SMN2KDM4EGAATSHR | |
| SCHEMBL16429902 | 0.71 | KMT2A (0.64) | MTNR1AMTNR1BSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL5023129 | 0.70 | SIGMAR1 (0.45) | SMN1; SMN2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL9491484 | 0.69 | MTNR1A (0.63) | MTNR1AMTNR1BSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL15473134 | 0.68 | PDE1B (0.40) | PDE1APDE1BPDE1C | |
| SCHEMBL4509396 | 0.68 | ACACB (0.64) | MTNR1AMTNR1BSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10391095-B2 | DNA-PK inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10391095-B2 | DNA-PK inhibitors | POLK, DTYMK, DCK | MTNR1A 4526/4885MTNR1B 4505/4885MCHR1 4703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.