SCHEMBL21297739

SCHEMBL21297739

Cc1c(C)c2cccnc2c2cnccc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.67
L3MBTL1 Q9Y468 2/20 0.67
HSP90AA1 P07900 1/20 0.67
KIT P10721 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
KDM4E B2RXH2 2/20 0.44
MEN1 O00255 2/20 0.44
MAPT P10636 2/20 0.44
KMT2A Q03164 2/20 0.44
GMNN O75496 1/20 0.44
ALDH1A1 P00352 1/20 0.44
LMNA P02545 1/20 0.44
NR3C1 P04150 1/20 0.44
TP53 P04637 1/20 0.44
CYP1A1 P04798 1/20 0.44
CYP1A2 P05177 1/20 0.44
LCK P06239 1/20 0.44
POLB P06746 1/20 0.44
CYP3A4 P08684 1/20 0.44
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21297756 0.92 NPC1 (0.67) NPC1L3MBTL1HSP90AA1KITSMN1; SMN2
SCHEMBL21297757 0.87 NPC1 (0.59) NPC1L3MBTL1HSP90AA1KITSMN1; SMN2
SCHEMBL15374724 0.84 NPC1 (0.48) NPC1L3MBTL1HSP90AA1SMN1; SMN2KDM4E
SCHEMBL14224306 0.84 L3MBTL1 (0.78) NPC1L3MBTL1HSP90AA1SMN1; SMN2KDM4E
SCHEMBL21297758 0.83 NPC1 (0.59) NPC1L3MBTL1HSP90AA1KITSMN1; SMN2
SCHEMBL250356 0.81 L3MBTL1 (1.00) NPC1L3MBTL1HSP90AA1SMN1; SMN2KDM4E
SCHEMBL19198129 0.80 NPC1 (0.48) NPC1L3MBTL1HSP90AA1SMN1; SMN2KDM4E
SCHEMBL20698679 0.80 NPC1 (0.48) NPC1L3MBTL1HSP90AA1SMN1; SMN2KDM4E
SCHEMBL21297745 0.80 NPC1 (0.48) NPC1L3MBTL1HSP90AA1KITSMN1; SMN2
SCHEMBL15374729 0.80 NPC1 (0.48) NPC1L3MBTL1HSP90AA1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-11063228-B2 Metal-assisted delayed fluorescent emitters employing benzo-imidazo-phenanthridine and analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2021-07-13 US disclosed
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2021-01-28 US disclosed
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-12-01 US disclosed
US-20200119288-A1 Metal-Assisted Delayed Fluorescent Emitters Employing Benzo-imidazo-phenanthridine and Analogues UNITED STATES DEPARTMENT OF ENERGY 2020-04-16 US disclosed
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2020-03-05 US disclosed
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS NPC1 4076/4885L3MBTL1 661/4885HSP90AA1 226/4885
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS NPC1 4076/4885L3MBTL1 661/4885HSP90AA1 226/4885
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS NPC1 4076/4885L3MBTL1 661/4885HSP90AA1 226/4885
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials KCNK4, TRPC4, TBRG4 NPC1 4601/4885L3MBTL1 1758/4885HSP90AA1 1287/4885
US-20200119288-A1 Metal-Assisted Delayed Fluorescent Emitters Employing Benzo-imidazo-phenanthridine and Analogues IK, HELZ, SUN2 NPC1 3036/4885L3MBTL1 1734/4885HSP90AA1 2330/4885
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials NT5C, HTR3D, IK NPC1 2661/4885L3MBTL1 1948/4885HSP90AA1 773/4885
US-11063228-B2 Metal-assisted delayed fluorescent emitters employing benzo-imidazo-phenanthridine and analogues IK, HELZ, SUN2 NPC1 3036/4885L3MBTL1 1734/4885HSP90AA1 2330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.