SCHEMBL21298053

SCHEMBL21298053

c1ccc2cc3c(cc2c1)c1nc2ccccc2nc1n1c2ccccc2nc31

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 7/20 0.49
MAPT P10636 6/20 0.49
HSD17B10 Q99714 3/20 0.49
POLB P06746 3/20 0.49
TP53 P04637 2/20 0.49
LMNA P02545 2/20 0.49
ALDH1A1 P00352 6/20 0.47
HPGD P15428 5/20 0.47
KMT2A Q03164 6/20 0.45
MEN1 O00255 5/20 0.45
CASP1 P29466 4/20 0.44
CASP7 P55210 4/20 0.44
TSHR P16473 3/20 0.44
HCRTR1 O43613 3/20 0.44
MAPK1 P28482 2/20 0.44
TDP1 Q9NUW8 2/20 0.44
NPC1 O15118 2/20 0.44
USP2 O75604 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
ATM Q13315 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21298052 0.87 KDM4E (0.42) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL21298050 0.86 KDM4E (0.51) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL21298231 0.86 KDM4E (0.43) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL21298230 0.84 KDM4E (0.44) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL21298047 0.82 MAPT (0.43) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL17993471 0.81 KDM4E (0.44) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL21298233 0.81 KDM4E (0.44) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL19959759 0.81 KDM4E (0.50) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL19959757 0.81 KDM4E (0.54) KDM4EMAPTHSD17B10POLBTP53
SCHEMBL21298229 0.78 KDM4E (0.48) KDM4EMAPTHSD17B10POLBTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2021-01-28 US disclosed
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-12-01 US disclosed
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2020-03-05 US disclosed
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885MAPT 467/4885HSD17B10 3931/4885
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885MAPT 467/4885HSD17B10 3931/4885
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS KDM4E 3740/4885MAPT 467/4885HSD17B10 3931/4885
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials KCNK4, TRPC4, TBRG4 KDM4E 731/4885MAPT 1680/4885HSD17B10 3165/4885
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials NT5C, HTR3D, IK KDM4E 2046/4885MAPT 2286/4885HSD17B10 3563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.