SCHEMBL21298366

SCHEMBL21298366

N#Cc1c(C#N)c(C#N)c2c(c1C#N)c1cc3ccccc3cc1c1cc3ccccc3n12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.38
ENPP3 O14638 1/20 0.36
MAP2K2 P36507 2/20 0.33
MAP2K1 Q02750 2/20 0.33
KDM4E B2RXH2 8/20 0.32
MAPT P10636 4/20 0.32
MEN1 O00255 4/20 0.32
KMT2A Q03164 4/20 0.32
LMNA P02545 3/20 0.32
NCOA3 Q9Y6Q9 3/20 0.32
HTT P42858 3/20 0.32
L3MBTL1 Q9Y468 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
PABPC1 P11940 1/20 0.32
CASP3 P42574 1/20 0.32
NCOA1 Q15788 1/20 0.32
SENP6 Q9GZR1 1/20 0.32
ALDH1A1 P00352 6/20 0.32
GAA P10253 4/20 0.32
NPSR1 Q6W5P4 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21298381 0.82 MAPK1 (0.39) MAPK1ENPP3MAP2K2MAP2K1KDM4E
SCHEMBL21297921 0.82 MAPK1 (0.39) MAPK1ENPP3MAP2K2MAP2K1KDM4E
SCHEMBL21298416 0.82 MAPK1 (0.37) MAPK1ENPP3MAP2K2MAP2K1KDM4E
SCHEMBL21298149 0.81 MAPK1 (0.36) MAPK1ENPP3MAP2K2MAP2K1KDM4E
SCHEMBL21298153 0.79 MAPK1 (0.40) MAPK1ENPP3MAP2K2MAP2K1KDM4E
SCHEMBL21298044 0.79 KDM4E (0.47) MAPK1KDM4EMAPTMEN1KMT2A
SCHEMBL21298147 0.74 HSD17B10 (0.35) MAPK1ENPP3KMT2AL3MBTL1ALDH1A1
SCHEMBL21298364 0.73 MEN1 (0.40) MAPK1ENPP3KDM4EMEN1KMT2A
SCHEMBL19563852 0.72 ENPP3 (0.41) MAPK1ENPP3MAP2K2MAP2K1KDM4E
SCHEMBL21298046 0.72 CDC25B (0.36) ENPP3KDM4EMAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNIV ARIZONA STATE (US) 2023-06-22 US disclosed
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2021-01-28 US disclosed
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2020-12-01 US disclosed
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS UNITED STATES DEPARTMENT OF ENERGY 2020-03-05 US disclosed
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2019-08-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210024526-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS MAPK1 4535/4885ENPP3 2826/4885MAP2K2 4505/4885
US-20200071330-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS MAPK1 4535/4885ENPP3 2826/4885MAP2K2 4505/4885
US-20230192695-A1 THERMALLY ASSISTED DELAYED FLUORESCENT MATERIALS WITH TRIAD-TYPE MATERIALS TTPA, TTC14, AAAS MAPK1 4535/4885ENPP3 2826/4885MAP2K2 4505/4885
US-10851106-B2 Substituted benzo[4,5]imidazo[1,2-F]phenanthridines, dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzofurophenanthridines and dibenzo[I.K]benzo[4,5]imidazo[1,2-F]benzo[4,5]thienophenanthridines as thermally assisted delayed fluorescent materials KCNK4, TRPC4, TBRG4 MAPK1 2756/4885ENPP3 4718/4885MAP2K2 1916/4885
US-10392387-B2 Substituted benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,8]naphthyridines, benzo[4,5]imidazo[1,2-a]phenanthro[9,10-c][1,5]naphthyridines and dibenzo[f,h]benzo[4,5]imidazo[2,1-a]pyrazino[2,3-c]isoquinolines as thermally assisted delayed fluorescent materials NT5C, HTR3D, IK MAPK1 3360/4885ENPP3 4323/4885MAP2K2 4130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.