Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.35 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529863 | 0.81 | NCF1 (0.47) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6529865 | 0.67 | PDE10A (0.50) | KDM4EABCC8KCNJ11KMT2AALDH1A1 | |
| SCHEMBL2871462 | 0.66 | ALDH1A1 (0.40) | KDM4EMAPTALDH1A1NPSR1MAPK1 | |
| SCHEMBL20975373 | 0.65 | KDM4E (0.46) | KDM4EALDH1A1RAB9ATP53NPC1 | |
| SCHEMBL7913463 | 0.65 | ALDH1A1 (0.37) | KDM4EMAPTALDH1A1NPSR1MAPK1 | |
| SCHEMBL2553820 | 0.64 | DYRK3 (0.62) | KDM4EMEN1KMT2AALDH1A1CDK2 | |
| SCHEMBL7916401 | 0.64 | ADORA2A (0.43) | KDM4EMAPTALDH1A1NPSR1MAPK1 | |
| SCHEMBL13349766 | 0.64 | NMT2 (0.48) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7916437 | 0.63 | ALDH1A1 (0.38) | KDM4EMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7914416 | 0.63 | ALDH1A1 (0.40) | KDM4EMAPTALDH1A1NPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019170150-A1 | PROTEIN DEGRADATION TARGETING BCR-ABL COMPOUND AND ANTITUMOR APPLICATION THEREOF | 上海科技大学 | 2019-09-12 | — | — | WO | disclosed |