Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 6/20 | 0.42 |
| ▸ | RELA | Q04206 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14741343 | 0.99 | CYP1A2 (0.46) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL21359924 | 0.87 | MEN1 (0.41) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL11264083 | 0.83 | NFKB1 (0.42) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL21358576 | 0.78 | SLC40A1 (0.44) | CYP2D6HIF1ANFKB1SMN1; SMN2MAPT | |
| SCHEMBL6740937 | 0.75 | ADRA2A (0.38) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL22235526 | 0.73 | GAA (0.38) | CYP1A2SMN1; SMN2GAAMAPTALDH1A1 | |
| SCHEMBL5265048 | 0.73 | GAA (0.41) | GAAMAPTMME | |
| SCHEMBL8129742 | 0.73 | GAA (0.41) | GAAMAPTMME | |
| SCHEMBL28810122 | 0.72 | CA1 (0.36) | CYP1A2CYP2D6CYP2C9CYP2C19HIF1A | |
| SCHEMBL444953 | 0.71 | GAA (0.69) | CYP1A2SMN1; SMN2GAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177937-A1 | SUBSTITUTED 2-PYRIDONE TRICYCLIC COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2019-09-19 | — | — | WO | claimed |
| WO-2019177937-A1 | SUBSTITUTED 2-PYRIDONE TRICYCLIC COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2019-09-19 | — | — | WO | disclosed |