Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALDH5A1 | P51649 | 3/20 | 0.39 |
| ▸ | ABAT | P80404 | 3/20 | 0.39 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783722 | 0.79 | KDM4E (0.50) | ALDH1A3KDM4EALDH1A1RAB9APTGS2 | |
| SCHEMBL3784501 | 0.79 | KDM4E (0.50) | ALDH1A3KDM4EALDH1A1RAB9APTGS2 | |
| SCHEMBL4310609 | 0.78 | KDM4E (0.48) | ALDH1A3KDM4EALDH1A1RAB9APTGS2 | |
| SCHEMBL29957404 | 0.78 | KDM4E (0.48) | ALDH1A3KDM4EALDH1A1RAB9APTGS2 | |
| SCHEMBL29421523 | 0.78 | ALDH1A1 (0.49) | ALDH1A3KDM4EALDH1A1RAB9APTGS2 | |
| SCHEMBL789495 | 0.78 | ALDH1A1 (0.49) | ALDH1A3KDM4EALDH1A1RAB9APTGS2 | |
| SCHEMBL31317426 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1RAB9APTGS2ALDH5A1 | |
| SCHEMBL28947075 | 0.78 | KDM4E (0.59) | KDM4EALDH1A1RAB9APTGS2ALDH5A1 | |
| SCHEMBL1711479 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1RAB9APTGS2ALDH5A1 | |
| SCHEMBL31500180 | 0.76 | ALDH1A1 (0.57) | ALDH1A3KDM4EALDH1A1ALDH3A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2022-04-07 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| EP-3765009-A1 | BICYCLIC ROR-GAMMA MODULATORS | Escalier Biosciences, BV (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177996-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11230555-B2 | Bicyclic RORγ modulators | RORC, RORA, RORB | ALDH1A3 168/4885KDM4E 3213/4885ALDH1A1 403/4885 |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | ALDH1A3 101/4885KDM4E 3482/4885ALDH1A1 287/4885 |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | ALDH1A3 101/4885KDM4E 3482/4885ALDH1A1 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.