Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 7/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28166698 | 0.79 | GSK3B (0.60) | CTSKNOTUMMTORGSK3BDYRK1A | |
| SCHEMBL30636341 | 0.79 | GSK3B (0.60) | CTSKNOTUMMTORGSK3BDYRK1A | |
| SCHEMBL213604 | 0.77 | CTSK (0.57) | CTSKNOTUMMTORWNT3ACHEK1 | |
| SCHEMBL22793399 | 0.74 | NOTUM (0.52) | CTSKNOTUMMTORWNT3ACHEK1 | |
| SCHEMBL22550481 | 0.73 | NOTUM (0.49) | CTSKNOTUMMTORWNT3ACHEK1 | |
| SCHEMBL22550526 | 0.73 | NOTUM (0.49) | CTSKNOTUMMTORWNT3ACHEK1 | |
| SCHEMBL20718135 | 0.73 | NOTUM (0.49) | CTSKNOTUMMTORWNT3ACHEK1 | |
| SCHEMBL215045 | 0.73 | NOTUM (0.49) | CTSKNOTUMMTORWNT3ACHEK1 | |
| SCHEMBL212869 | 0.73 | CTSK (0.51) | CTSKNOTUMMTORWNT3ACHEK1 | |
| SCHEMBL2574304 | 0.73 | EPHX1 (0.61) | CTSKNOTUMCHEK1ALDH1A1QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |