Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.47 |
| ▸ | RARB | P10826 | 7/20 | 0.46 |
| ▸ | RARA | P10276 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20157516 | 0.85 | ALDH1A1 (0.48) | THRB | |
| SCHEMBL6936245 | 0.82 | THRA (0.56) | THRATHRBRARBRARA | |
| SCHEMBL21362558 | 0.82 | DPP4 (0.40) | THRATHRB | |
| SCHEMBL20157560 | 0.80 | PTPN1 (0.43) | — | |
| SCHEMBL21362538 | 0.80 | SRD5A2 (0.39) | THRB | |
| SCHEMBL1252299 | 0.79 | GAA (0.50) | THRB | |
| SCHEMBL20157579 | 0.79 | TP53 (0.38) | THRB | |
| SCHEMBL20157580 | 0.79 | LMNA (0.37) | THRB | |
| SCHEMBL11871709 | 0.79 | PPARA (0.68) | PPARARARBRARARARGPPARG | |
| SCHEMBL20157757 | 0.78 | LMNA (0.50) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3539960-A1 | NITROGENOUS MACROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | Luoxin Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-09-18 | — | — | EP | disclosed |