Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 6/20 | 0.47 |
| ▸ | PPIB | P23284 | 4/20 | 0.47 |
| ▸ | PPIG | Q13427 | 2/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.40 |
| ▸ | ITGA2 | P17301 | 4/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21376456 | 0.89 | ACE (0.47) | CA1CA2CA7CA14ALDH1A1 | |
| SCHEMBL21358724 | 0.89 | POLB (0.54) | ALDH1A1POLBITGB1ITGA2ITGA4 | |
| SCHEMBL21358725 | 0.89 | POLB (0.54) | ALDH1A1POLBITGB1ITGA2ITGA4 | |
| SCHEMBL21376443 | 0.86 | PPARG (0.54) | ALDH1A1POLBPPARGSMN1; SMN2ANPEP | |
| SCHEMBL21376446 | 0.79 | OPRM1 (0.52) | ALDH1A1LMNAPOLB | |
| SCHEMBL21376447 | 0.76 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2ANPEP | |
| SCHEMBL21376371 | 0.76 | ITGB1 (0.48) | ALDH1A1LMNAITGB1ITGA2ITGA4 | |
| SCHEMBL15652114 | 0.75 | PPID (0.65) | PPIDPPIBPPIGPPIAALDH1A1 | |
| SCHEMBL21376626 | 0.74 | ITGA4 (0.55) | PPIDPPIBALDH1A1LMNAITGB1 | |
| SCHEMBL15939528 | 0.73 | PPID (0.65) | PPIDPPIBPPIGPPIAEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11597727-B2 | Inhibitors of integrin alpha 2 beta 1 and methods of use | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-03-07 | — | — | US | disclosed |
| US-20210387986-A1 | INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2021-12-16 | — | — | US | disclosed |
| WO-2019178248-A1 | INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11597727-B2 | Inhibitors of integrin alpha 2 beta 1 and methods of use | ITGB1, ITGB2, ITGA2 | PPID 2968/4885PPIB 1774/4885PPIG 2620/4885 |
| US-20210387986-A1 | INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE | ITGB1, ITGB2, ITGA2 | PPID 2968/4885PPIB 1774/4885PPIG 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.