SCHEMBL2138745

SCHEMBL2138745

CNC(=O)c1cc(Cl)cc(Cl)c1NC(=O)c1cc(Br)nn1-c1ccccc1Cl

nearest known ligand 0.64

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.36
RIPK1 Q13546 1/20 0.36
KMT2A Q03164 4/20 0.35
CNR2 P34972 1/20 0.35
MEN1 O00255 3/20 0.34
TP53 P04637 1/20 0.34
NPY5R Q15761 1/20 0.34
NTRK1 P04629 1/20 0.34
WNT3A P56704 1/20 0.34
MALT1 Q9UDY8 2/20 0.33
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL782140 0.85 DHODH (0.42) KMT2ANTRK1MALT1
SCHEMBL2138320 0.82 MEN1 (0.35) RIPK1KMT2AMEN1TP53
SCHEMBL10140197 0.82 DHODH (0.41) L3MBTL1KMT2ANTRK1MALT1
SCHEMBL29369827 0.82 SCN9A (0.34) KMT2AMEN1MAPTNPSR1POLB
SCHEMBL12528155 0.82 KMT2A (0.44) L3MBTL1KMT2AMEN1TP53NTRK1
SCHEMBL12175343 0.82 SCN9A (0.34) KMT2AMEN1MAPTNPSR1POLB
SCHEMBL15187947 0.79 LMNA (0.32) L3MBTL1KMT2AMEN1MAPTNPSR1
SCHEMBL15187946 0.79 SCN9A (0.32) L3MBTL1KMT2AMEN1
SCHEMBL4664524 0.79 TSHR (0.38) RIPK1KMT2ACNR2TP53ALDH1A1
SCHEMBL12528992 0.79 TP53 (0.35) RIPK1KMT2ACNR2MEN1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US claimed
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2018-06-21 US disclosed
US-9826737-B2 Solid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (US) 2017-11-28 US disclosed
US-20170215419-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE E I DUPONT DE NEMOURS AND COMPANY 2017-08-03 US disclosed
US-9332756-B2 Liquid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (US) 2016-05-10 US disclosed
WO-2016019013-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2016-02-04 WO disclosed
US-8709513-B2 Liquid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (DE) 2014-04-29 US disclosed
US-20140005048-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-02 US disclosed
EP-2094092-B1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES DU PONT (US) 2012-10-31 EP disclosed
US-20110059846-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E. I. DU PONT DE NEMOURS AND COMPANY 2011-03-10 US disclosed
US-20100137374-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2010-06-03 US disclosed
US-20100055084-A1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-03-04 US disclosed
EP-1968382-B1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES DU PONT (US) 2009-09-16 EP disclosed
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US disclosed
EP-2001300-A2 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2008-12-17 EP disclosed
US-20080305093-A1 Liquid Formulations of Carboxamide Arthropodicides FMC IP TECHNOLOGY GMBH (CH) 2008-12-11 US disclosed
WO-2008021152-A2 AGRONOMIC METHOD E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-02-21 WO disclosed
WO-2007126636-A2 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-11-08 WO disclosed
US-20070184018-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2007-08-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137374-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES FAAH, FAAH2, CNR2 L3MBTL1 3972/4885RIPK1 3364/4885KMT2A 1871/4885
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS NASP, CPS1, CYP11A1 L3MBTL1 494/4885RIPK1 2069/4885KMT2A 1122/4885
US-20080305093-A1 Liquid Formulations of Carboxamide Arthropodicides FAAH, C9, FAAH2 L3MBTL1 1070/4885RIPK1 968/4885KMT2A 1698/4885
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 L3MBTL1 3359/4885RIPK1 4048/4885KMT2A 1517/4885
US-20070184018-A1 Anthranilamide insecticides F12, CBR3, F3 L3MBTL1 468/4885RIPK1 3800/4885KMT2A 1133/4885
US-20100055084-A1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES FAAH, CHIA, FAAH2 L3MBTL1 1118/4885RIPK1 1414/4885KMT2A 1243/4885
US-20140005048-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES FAAH, CNR2, FAAH2 L3MBTL1 4414/4885RIPK1 3873/4885KMT2A 2958/4885
US-20110059846-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES FAAH, CNR2, FAAH2 L3MBTL1 4414/4885RIPK1 3873/4885KMT2A 2958/4885
US-20170215419-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 L3MBTL1 3359/4885RIPK1 4048/4885KMT2A 1517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.