Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6111389 | 0.86 | CYP2C9 (0.50) | CYP3A4CYP2C9CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL2824494 | 0.84 | CYP2C19 (0.49) | CYP3A4CYP2C9CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL5948337 | 0.83 | CYP3A4 (0.67) | CYP3A4CYP2C9CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL5667467 | 0.83 | ALDH1A1 (0.48) | CYP3A4CYP2C9CYP2C19ALDH1A1NPC1 | |
| SCHEMBL2139709 | 0.82 | ALDH1A1 (0.41) | CYP3A4CYP2C9CYP2C19ALDH1A1PDK1 | |
| SCHEMBL18459510 | 0.80 | ALDH1A1 (0.50) | CYP3A4CYP2C9CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL6110413 | 0.79 | LMNA (0.47) | CYP3A4CYP2C9CYP2C19ALDH1A1PDK1 | |
| SCHEMBL6111376 | 0.79 | RIPK1 (0.43) | CYP3A4CYP2C9CYP2C19ALDH1A1CYP2D6 | |
| SCHEMBL10294037 | 0.79 | ENPP2 (0.45) | PDK1PDK2PDK3PDK4IKBKB | |
| SCHEMBL28665575 | 0.76 | CYP4F2 (0.42) | CYP3A4CYP2C9CYP2C19ALDH1A1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629271-B2 | Compounds | ASTRAZENECA AB (GB) | 2014-01-14 | — | — | US | disclosed |
| US-20120322788-A1 | Compouds | PULMAGEN THERAPEUTICS (SYNERGY) LIMITED (GB) | 2012-12-20 | — | — | US | disclosed |
| EP-2242759-B1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2012-09-12 | — | — | EP | disclosed |
| US-8148373-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-04-03 | — | — | US | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322788-A1 | Compouds | PKD1, SBDS, ABCB11 | CYP3A4 76/4885CYP2C9 31/4885CYP2C19 19/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | CYP3A4 60/4885CYP2C9 22/4885CYP2C19 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.