Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 3/20 | 0.40 |
| ▸ | LITAF | Q99732 | 3/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12791679 | 0.78 | CDK9 (0.57) | GAAALOX15HRH3JAK1AURKA | |
| SCHEMBL21354604 | 0.72 | EGFR (0.40) | ALDH1A1GLAMAPK1UBE2NNPSR1 | |
| SCHEMBL18250748 | 0.72 | CCR5 (0.58) | GAAALOX15KDRCCNT1CDK9 | |
| SCHEMBL6245431 | 0.70 | TP53 (0.43) | JAK1JAK2TNFLITAFMAPT | |
| SCHEMBL23409153 | 0.70 | JAK1 (0.47) | GAAALOX15JAK1JAK2CCNT1 | |
| SCHEMBL24458124 | 0.70 | JAK1 (0.47) | GAAALOX15JAK1JAK2CCNT1 | |
| SCHEMBL21354755 | 0.70 | EGFR (0.39) | ALDH1A1GLAMAPK1UBE2NNPSR1 | |
| SCHEMBL3448194 | 0.69 | GAA (0.61) | GAAALOX15KDRCCNT1CDK9 | |
| SCHEMBL18250718 | 0.68 | GAA (0.64) | GAAALOX15CCNT1CDK9HCAR1 | |
| SCHEMBL21390931 | 0.68 | ALDH1A1 (0.62) | GAACCNT1CDK9PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019183148-A1 | KV7 CHANNEL ACTIVATORS COMPOSITIONS AND METHODS OF USE | KNOPP BIOSCIENCES LLC (US) | 2019-09-26 | — | — | WO | disclosed |