Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.59 |
| ▸ | JAK3 | P52333 | 8/20 | 0.55 |
| ▸ | BTK | Q06187 | 3/20 | 0.55 |
| ▸ | JAK2 | O60674 | 6/20 | 0.52 |
| ▸ | JAK1 | P23458 | 6/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | F13A1 | P00488 | 1/20 | 0.49 |
| ▸ | TGM1 | P22735 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21392906 | 0.86 | TGM2 (0.59) | TGM2JAK3BTKJAK2JAK1 | |
| SCHEMBL16628031 | 0.78 | RAF1 (0.61) | METRAF1 | |
| SCHEMBL21295393 | 0.77 | MAPT (0.64) | NTRK1MAPTKDM4ERAF1ALDH1A1 | |
| SCHEMBL9017578 | 0.76 | TGM2 (1.00) | TGM2EGFRMAPTF13A1TGM1 | |
| SCHEMBL8151744 | 0.75 | MTNR1B (0.74) | TGM2RAF1ALDH1A1 | |
| SCHEMBL21392902 | 0.75 | TGM2 (0.71) | TGM2BTKEGFRBLKALDH1A1 | |
| SCHEMBL14341775 | 0.75 | TGM2 (0.86) | TGM2EGFRMAPTF13A1TGM1 | |
| SCHEMBL23421241 | 0.75 | BTK (0.68) | JAK3BTKJAK2JAK1EGFR | |
| SCHEMBL6014834 | 0.75 | RAB9A (0.67) | NTRK1MAPTKDM4ERAF1ALDH1A1 | |
| SCHEMBL23243736 | 0.75 | CTSC (0.83) | JAK3BTKJAK2JAK1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | FRONTIER MEDICINES CORPORATION | 2019-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190290778-A1 | METHODS AND COMPOUNDS FOR TARGETED AUTOPHAGY | ATG7, BECN1, SQSTM1 | TGM2 2225/4885JAK3 4008/4885BTK 4180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.