Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21393412 | 0.80 | TYK2 (0.35) | ALDH1A1JAK2JAK1TYK2 | |
| SCHEMBL382884 | 0.70 | TYK2 (0.39) | KDM4EALDH1A1SMN1; SMN2HSD17B10JAK2 | |
| SCHEMBL30765091 | 0.70 | TYK2 (0.39) | KDM4EALDH1A1SMN1; SMN2HSD17B10JAK2 | |
| SCHEMBL27532136 | 0.67 | TYK2 (0.37) | KDM4EMEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL9631416 | 0.63 | DPP4 (0.42) | KDM4EMEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL18676076 | 0.63 | PLAU (0.49) | KDM4EMEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL27567268 | 0.62 | P2RX7 (0.40) | KDM4ENPC1ALDH1A1POLBHPGD | |
| SCHEMBL21393825 | 0.62 | CSNK1A1 (0.33) | ALDH1A1POLBSMN1; SMN2CYP2C19 | |
| SCHEMBL21393782 | 0.61 | CYP1A2 (0.32) | ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL21014435 | 0.60 | ACACB (0.41) | JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |