Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21393825 | 0.81 | CSNK1A1 (0.33) | ALDH1A1THRB | |
| SCHEMBL21393794 | 0.80 | KDM4E (0.34) | TYK2JAK2JAK1ALDH1A1 | |
| SCHEMBL382884 | 0.76 | TYK2 (0.39) | TYK2JAK2JAK1ALDH1A1THRB | |
| SCHEMBL30765091 | 0.76 | TYK2 (0.39) | TYK2JAK2JAK1ALDH1A1THRB | |
| SCHEMBL27532136 | 0.73 | TYK2 (0.37) | TYK2JAK2JAK1ALDH1A1THRB | |
| SCHEMBL9631416 | 0.68 | DPP4 (0.42) | TYK2JAK2JAK1ALDH1A1 | |
| SCHEMBL21393778 | 0.68 | MEN1 (0.42) | ALDH1A1 | |
| SCHEMBL22210022 | 0.67 | KDM5A (0.34) | TYK2GAA | |
| SCHEMBL27567268 | 0.67 | P2RX7 (0.40) | TYK2JAK2JAK1ALDH1A1GAA | |
| SCHEMBL976845 | 0.64 | ALDH1A1 (0.61) | TYK2JAK2JAK1ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |