Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CD38 | P28907 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21395082 | 0.86 | NPC1 (0.43) | GRM5RAB9ANPC1PPARGTP53 | |
| SCHEMBL22479673 | 0.78 | NPC1 (0.47) | GRM5RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL21395020 | 0.78 | CACNA1H (0.43) | GRM5RAB9ANPC1PPARGCYP1A2 | |
| SCHEMBL21394653 | 0.78 | RAB9A (0.42) | GRM5RAB9ANPC1PPARGTP53 | |
| SCHEMBL21395025 | 0.77 | NPC1 (0.45) | RAB9ANPC1MEN1KMT2APPARG | |
| SCHEMBL21394702 | 0.77 | MAOB (0.44) | RAB9ANPC1TP53CYP1A2CYP2D6 | |
| SCHEMBL21394713 | 0.76 | NPC1 (0.44) | RAB9ANPC1MEN1KMT2APPARG | |
| SCHEMBL21395019 | 0.76 | PARP1 (0.53) | RAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL21394699 | 0.76 | FFAR2 (0.42) | RAB9ANPC1PPARGSMN1; SMN2BACE1 | |
| SCHEMBL29357599 | 0.76 | NPC1 (0.47) | RAB9ANPC1MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |