Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2141828 | 0.83 | GAA (0.40) | GAAALDH1A1SMN1; SMN2HSD17B10MGAM | |
| SCHEMBL19736433 | 0.81 | TSHR (0.38) | HSP90AB1TP53TSHRCYP4F2CYP4A11 | |
| SCHEMBL2140882 | 0.80 | MTNR1A (0.33) | — | |
| SCHEMBL21160122 | 0.78 | TP53 (0.37) | HSP90AB1TP53TSHRCYP4F2CYP4A11 | |
| SCHEMBL2141233 | 0.76 | — | — | |
| SCHEMBL2139653 | 0.75 | ALDH1A1 (0.36) | ALDH1A1KDM4ESMN1; SMN2HPGDHTT | |
| SCHEMBL2142693 | 0.72 | ALDH1A1 (0.38) | ALDH1A1KDM4ESMN1; SMN2HPGDMAPT | |
| SCHEMBL13331957 | 0.71 | ALDH1A1 (0.33) | ALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL1171891 | 0.70 | — | — | |
| SCHEMBL11799159 | 0.67 | GAA (0.31) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940920-B2 | Method for preparation of (2-hydroxy-3-oxo-cyclopent-1-enyl)-acetic acid esters | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2015-01-27 | — | — | US | disclosed |
| US-20140378698-A1 | Method for preparation of (2-hydroxy-3-oxo-cyclopent-1-enyl)-acetic acid esters | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2014-12-25 | — | — | US | disclosed |
| US-8148568-B2 | Esters of (2-hydroxy-3-oxo-cyclopent-1-enyl) acetic acid and their use for preparing (−)-R-homocitric acid gamma-lactone, (+)-S-homocitric acid gamma-lactone and the corresponding (−)-R-homocitric acid and (+)-S-homocitric acid salts | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2012-04-03 | — | — | US | disclosed |
| US-20090187041-A1 | ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2009-07-23 | — | — | US | disclosed |
| WO-2007137593-A1 | ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS | TALLINN UNIVERSITY OF TECHNOLOGY (EE) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378698-A1 | Method for preparation of (2-hydroxy-3-oxo-cyclopent-1-enyl)-acetic acid esters | HACL2, HSD17B12, CYP8B1 | HSP90AB1 1272/4885TP53 3414/4885TSHR 3553/4885 |
| US-20090187041-A1 | ESTERS OF (2-HYDROXY-3-OXO-CYCLOPENT-1-ENYL) ACETIC ACID AND THEIR USE FOR PREPARING (-)-R-HOMOCITRIC ACID GAMMA-LACTONE, (+)-S-HOMOCITRIC ACID GAMMA-LACTONE AND THE CORRESPONDING (-)-R-HOMOCITRIC ACID AND (+)-S-HOMOCITRIC ACID SALTS | HACL2, CYP8B1, HCAR1 | HSP90AB1 950/4885TP53 2661/4885TSHR 2920/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.