Acridine

Acridine

SCHEMBL21408390

CCCS(=O)(=O)O.c1ccc2nc3ccccc3cc2c1

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.54
HPGD P15428 2/20 0.54
GLA P06280 1/20 0.54
MAPT P10636 1/20 0.54
ACHE P22303 1/20 0.54
GAA P10253 4/20 0.42
KDM4E B2RXH2 3/20 0.42
HTR3A P46098 1/20 0.42
STAT3 P40763 1/20 0.42
TLR8 Q9NR97 6/20 0.41
POLB P06746 1/20 0.41
TSHR P16473 1/20 0.40
MAP4K4 O95819 1/20 0.40
CDK1 P06493 1/20 0.40
CDK2 P24941 1/20 0.40
GSK3A P49840 1/20 0.40
GSK3B P49841 1/20 0.40
LIMK1 P53667 1/20 0.40
CDK5 Q00535 1/20 0.40
DYRK1A Q13627 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Naphthalene SCHEMBL12468496 0.85 GAA (0.43) ALDH1A1HPGDGAAKDM4EPOLB
Naphthalene SCHEMBL30775918 0.85 GAA (0.43) ALDH1A1HPGDGAAKDM4EPOLB
Acridine SCHEMBL8000372 0.83 ALDH1A1 (0.65) ALDH1A1HPGDGLAMAPTACHE
Acridine SCHEMBL11600717 0.82 ALDH1A1 (0.71) ALDH1A1HPGDGLAMAPTACHE
Acridine SCHEMBL10831095 0.82 ALDH1A1 (0.71) ALDH1A1HPGDGLAMAPTACHE
Quinoline SCHEMBL27825807 0.79 ALDH1A1 (0.57) ALDH1A1MAPTGAAKDM4EPOLB
Acridine SCHEMBL2331753 0.78 ALDH1A1 (0.71) ALDH1A1HPGDGLAMAPTACHE
Acridine SCHEMBL2823221 0.78 ALDH1A1 (0.58) ALDH1A1HPGDGLAMAPTACHE
Acridine SCHEMBL7126489 0.77 TLR8 (0.50) ALDH1A1HPGDGLAMAPTACHE
Acridine SCHEMBL29014290 0.77 ALDH1A1 (0.68) ALDH1A1HPGDGLAMAPTACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019184249-A1 DIRECT CHEMILUMINESCENCE KIT FOR DETECTING MECHANO-GROWTH FACTOR AND E PEPTIDE THEREOF, AND PREPARATION METHOD THEREFOR 苏州长光华医生物医学工程有限公司 2019-10-03 WO claimed
CN-112485452-A Method for quantifying protein abundance by using metal clusters as artificial antibodies 北京工业大学 2021-03-12 CN disclosed
WO-2019184249-A1 DIRECT CHEMILUMINESCENCE KIT FOR DETECTING MECHANO-GROWTH FACTOR AND E PEPTIDE THEREOF, AND PREPARATION METHOD THEREFOR 苏州长光华医生物医学工程有限公司 2019-10-03 WO disclosed