Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | GLA | P06280 | 2/20 | 0.71 |
| ▸ | ACHE | P22303 | 1/20 | 0.71 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.45 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL10831095 | 1.00 | ALDH1A1 (0.71) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL8000372 | 0.91 | ALDH1A1 (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL2140243 | 0.86 | ALDH1A1 (0.71) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL1051621 | 0.86 | ALDH1A1 (0.71) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL2823221 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL3252417 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HPGDMAPTGLAACHE | |
| Phenazine SCHEMBL2923781 | 0.85 | MAPT (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Phenazine SCHEMBL8564741 | 0.85 | MAPT (0.65) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL1772714 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL8339 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HPGDMAPTGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4093522-A | WITH WATER SOLUBLE PYRIDINIUM, QUINOLINIUM OR ACRIDINIUM SULFATE AND HALIDE | DILLENBERG HORST | 1978-06-06 | — | — | US | claimed |
| CN-118103706-A | DHEAS assay, reagents for DHEAS assay, and methods of making and using the same | 美国西门子医学诊断股份有限公司 | 2024-05-28 | — | — | CN | disclosed |
| US-4093522-A | WITH WATER SOLUBLE PYRIDINIUM, QUINOLINIUM OR ACRIDINIUM SULFATE AND HALIDE | DILLENBERG HORST | 1978-06-06 | — | — | US | disclosed |