Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Acridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | GLA | P06280 | 2/20 | 0.65 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine SCHEMBL11600717 | 0.91 | ALDH1A1 (0.71) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL10831095 | 0.91 | ALDH1A1 (0.71) | ALDH1A1HPGDMAPTGLAACHE | |
| Phenazine SCHEMBL1750964 | 0.86 | MAPT (0.58) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| Acridine SCHEMBL2823221 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HPGDMAPTGLAACHE | |
| Anthracene SCHEMBL21295279 | 0.84 | L3MBTL1 (0.48) | SMN1; SMN2TDP1LMNAKMT2A | |
| SCHEMBL27690243 | 0.83 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL21408390 | 0.83 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL1051621 | 0.82 | ALDH1A1 (0.71) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL2140243 | 0.82 | ALDH1A1 (0.71) | ALDH1A1HPGDMAPTGLAACHE | |
| Acridine SCHEMBL3252417 | 0.82 | ALDH1A1 (0.58) | ALDH1A1HPGDMAPTGLAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0804414-A4 | COMPLEMENTARY DNA AND TOXINS | SLOAN KETTERING INST CANCER (US) | 2000-04-12 | — | — | EP | disclosed |
| EP-0804414-A1 | COMPLEMENTARY DNA AND TOXINS | Sloan-Kettering Institute For Cancer Research (US) | 1997-11-05 | — | — | EP | disclosed |
| US-5652350-A | Complementary DNA and toxins | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1997-07-29 | — | — | US | disclosed |
| US-5571937-A | VIRICIDES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1996-11-05 | — | — | US | disclosed |
| WO-1995031434-A1 | COMPLEMENTARY DNA AND TOXINS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1995-11-23 | — | — | WO | disclosed |