Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Diazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 8/20 | 0.97 |
| ▸ | GABRG2 known ✓ | P18507 | 8/20 | 0.97 |
| ▸ | GABRB3 known ✓ | P28472 | 8/20 | 0.97 |
| ▸ | GABRA5 known ✓ | P31644 | 8/20 | 0.97 |
| ▸ | GABRA3 known ✓ | P34903 | 8/20 | 0.97 |
| ▸ | GABRA2 known ✓ | P47869 | 8/20 | 0.97 |
| ▸ | GABRB2 known ✓ | P47870 | 5/20 | 0.97 |
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.97 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.97 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.97 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.97 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.97 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.97 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.97 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.97 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.97 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.97 |
| ▸ | ALB | P02768 | 1/20 | 0.97 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diazepam SCHEMBL29362687 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL1019217 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL9278054 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL21442 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL16922183 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL3043280 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL11345350 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL17555369 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL6014348 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL4370625 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952398-B2 | Chromatographic method for collecting blood coagulation factor VII with high yield | KM BIOLOGICS CO., LTD. (JP) | 2024-04-09 | — | — | US | disclosed |
| CN-117580824-A | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2024-02-20 | — | — | CN | disclosed |
| US-20230201787-A1 | SYSTEMS AND METHODS FOR SYNTHESIZING CHEMICAL PRODUCTS, INCLUDING ACTIVE PHARMACEUTICAL INGREDIENTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-06-29 | — | — | US | disclosed |
| US-11565230-B2 | Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-01-31 | — | — | US | disclosed |
| CN-115335058-A | Nerve cell degeneration inhibitor | 国立大学法人京都大学 | 2022-11-11 | — | — | CN | disclosed |
| EP-3952852-A1 | PROPHYLACTIC EFFICACY OF SEROTONIN 4 RECEPTOR AGONISTS AGAINST STRESS | The Trustees of Columbia University in the City of New York (US) | 2022-02-16 | — | — | EP | disclosed |
| US-20220031684-A1 | PROPHYLACTIC EFFICACY OF SEROTONIN 4 RECEPTOR AGONISTS AGAINST STRESS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 2022-02-03 | — | — | US | disclosed |
| EP-3560946-B1 | CHROMATOGRAPHIC METHOD FOR COLLECTING BLOOD COAGULATION FACTOR VII WITH HIGH YIELD | KM BIOLOGICS CO LTD (JP) | 2022-02-02 | — | — | EP | disclosed |
| CN-113924087-A | Prophylactic efficacy of serotonin 4receptor agonists against stress | 纽约市哥伦比亚大学理事会 | 2022-01-11 | — | — | CN | disclosed |
| US-20210292359-A1 | CHROMATOGRAPHIC METHOD FOR COLLECTING BLOOD COAGULATION FACTOR VII WITH HIGH YIELD | KM BIOLOGICS CO., LTD. (JP) | 2021-09-23 | — | — | US | disclosed |
| WO-2020210393-A1 | PROPHYLACTIC EFFICACY OF SEROTONIN 4 RECEPTOR AGONISTS AGAINST STRESS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-10-15 | — | — | WO | disclosed |
| US-10780410-B2 | Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-09-22 | — | — | US | disclosed |
| US-20200095276-A1 | CHROMATOGRAPHIC METHOD FOR COLLECTING BLOOD COAGULATION FACTOR VII WITH HIGH YIELD | KM BIOLOGICS CO., LTD. (JP) | 2020-03-26 | — | — | US | disclosed |
| EP-3560946-A1 | CHROMATOGRAPHIC METHOD FOR COLLECTING BLOOD COAGULATION FACTOR VII WITH HIGH YIELD | KM Biologics Co., Ltd. (JP) | 2019-10-30 | — | — | EP | disclosed |
| US-20180207604-A1 | SYSTEMS AND METHODS FOR SYNTHESIZING CHEMICAL PRODUCTS, INCLUDING ACTIVE PHARMACEUTICAL INGREDIENTS | Massachusettts Institute of Technology (US) | 2018-07-26 | — | — | US | disclosed |
| EP-3180118-A1 | SYSTEMS AND METHODS FOR SYNTHESIZING CHEMICAL PRODUCTS, INCLUDING ACTIVE PHARMACEUTICAL INGREDIENTS | Massachusetts Institute Of Technology (US) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016025803-A1 | SYSTEMS AND METHODS FOR SYNTHESIZING CHEMICAL PRODUCTS, INCLUDING ACTIVE PHARMACEUTICAL INGREDIENTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-02-18 | — | — | WO | disclosed |
| US-6908915-B1 | Tricyclic compounds and their uses as antiarrhythmic antifibrillatory and defibrillatory agents | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD. (IL) | 2005-06-21 | — | — | US | disclosed |
| WO-2001015656-A9 | TRICYCLIC COMPOUNDS AND THEIR USES AS ANTIARRHYTHMIC ANTIFIBRILLATORY AND DEFIBRILLATORY AGENTS | TECHNION RES & DEV FOUNDATION (IL) | 2002-04-18 | — | — | WO | disclosed |
| WO-2001015656-A2 | TRICYCLIC COMPOUNDS AND THEIR USES AS ANTIARRHYTHMIC ANTIFIBRILLATORY AND DEFIBRILLATORY AGENTS | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2001-03-08 | — | — | WO | disclosed |