Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Diazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 8/20 | 0.97 |
| ▸ | GABRG2 known ✓ | P18507 | 8/20 | 0.97 |
| ▸ | GABRB3 known ✓ | P28472 | 8/20 | 0.97 |
| ▸ | GABRA5 known ✓ | P31644 | 8/20 | 0.97 |
| ▸ | GABRA3 known ✓ | P34903 | 8/20 | 0.97 |
| ▸ | GABRA2 known ✓ | P47869 | 8/20 | 0.97 |
| ▸ | GABRB2 known ✓ | P47870 | 5/20 | 0.97 |
| ▸ | GABRP known ✓ | O00591 | 2/20 | 0.97 |
| ▸ | GABRD known ✓ | O14764 | 2/20 | 0.97 |
| ▸ | GABRB1 known ✓ | P18505 | 2/20 | 0.97 |
| ▸ | GABRA4 known ✓ | P48169 | 2/20 | 0.97 |
| ▸ | GABRE known ✓ | P78334 | 2/20 | 0.97 |
| ▸ | GABRA6 known ✓ | Q16445 | 2/20 | 0.97 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 2/20 | 0.97 |
| ▸ | GABRG3 known ✓ | Q99928 | 2/20 | 0.97 |
| ▸ | GABRQ known ✓ | Q9UN88 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.97 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.97 |
| ▸ | ALB | P02768 | 1/20 | 0.97 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diazepam SCHEMBL29362687 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL1019217 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL16922183 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL21442 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL9278054 | 0.99 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL3043280 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL11345350 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL6298785 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL6014348 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Diazepam SCHEMBL17555369 | 0.97 | GABRA1 (0.97) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090021810-A1 | METHOD OF SCENE BALANCE USING PANCHROMATIC PIXELS | EASTMAN KODAK COMPANY | 2009-01-22 | — | — | US | disclosed |