Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 1/20 | 0.37 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.37 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.37 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL2248161 | 0.87 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP1A2LMNATOP2ACYP4F2 | |
| Methyl Alcohol SCHEMBL6759312 | 0.84 | MGAM (0.52) | SMN1; SMN2CYP1A2LMNACYP4F2CYP4A11 | |
| Water SCHEMBL1110192 | 0.84 | MGAM (0.52) | SMN1; SMN2CYP1A2LMNACYP4F2CYP4A11 | |
| Methyl Alcohol SCHEMBL2707570 | 0.84 | MGAM (0.52) | SMN1; SMN2CYP1A2LMNACYP4F2CYP4A11 | |
| Water SCHEMBL27860286 | 0.84 | MGAM (0.52) | SMN1; SMN2CYP1A2LMNACYP4F2CYP4A11 | |
| Pyridine SCHEMBL27917106 | 0.84 | CYP1A2 (0.55) | SMN1; SMN2TBXAS1CYP1A2LMNATOP2A | |
| SCHEMBL363334 | 0.82 | MGAM (0.55) | SMN1; SMN2CYP1A2LMNACYP4F2CYP4A11 | |
| Succinic Acid Diethyl Ester SCHEMBL27830938 | 0.82 | MGAM (0.55) | SMN1; SMN2CYP1A2LMNACYP4F2CYP4A11 | |
| Succinic Acid Diethyl Ester SCHEMBL27966388 | 0.82 | MGAM (0.55) | SMN1; SMN2CYP1A2LMNACYP4F2CYP4A11 | |
| SCHEMBL262913 | 0.82 | MGAM (0.55) | SMN1; SMN2CYP1A2LMNACYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2690178-B1 | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same | UNIV OKLAHOMA (US) | 2021-12-22 | — | — | EP | disclosed |
| US-20160053290-A1 | Production of Defined Monodisperse Heparosan Polymers and Unnatural Polymers with Polysaccharide Synthases | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2016-02-25 | — | — | US | disclosed |
| US-9200024-B2 | Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2015-12-01 | — | — | US | disclosed |
| EP-2690178-A1 | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same | The Board Of Regents Of The University Of Oklahoma (US) | 2014-01-29 | — | — | EP | disclosed |
| US-20120108802-A1 | PRODUCTION OF DEFINED MONODISPERSE HEPAROSAN POLYMERS AND UNNATURAL POLYMERS WITH POLYSACCHARIDE SYNTHASES | DEANGELIS PAUL L (US) | 2012-05-03 | — | — | US | disclosed |
| US-8088604-B2 | Production of defined monodisperse heparosan polymers and unnatural polymers with polysaccharide synthases | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2012-01-03 | — | — | US | disclosed |
| US-7741091-B2 | Methods of producing hyaluronic acid and chimeric and hybrid glycosaminoglycan polymers | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2010-06-22 | — | — | US | disclosed |
| US-7579173-B2 | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using the same | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2009-08-25 | — | — | US | disclosed |
| US-7575904-B2 | Using the hyaluronate synthase from Pasteurella multocida; coatings for biomaterials wherein the coatings provide protective properties to the biomaterial and/or act as a bioadhesive; coatings could be applied to electrical devices, sensors, catheters | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2009-08-18 | — | — | US | disclosed |
| EP-2079846-A2 | TARGETED GLYCOSAMINOGLYCAN POLYMERS BY POLYMER GRAFTING AND METHODS OF MAKING AND USING SAME | The Board Of Rengents Of The University Of Oklahoma (US) | 2009-07-22 | — | — | EP | disclosed |
| US-20060188966-A1 | Natural, chimeric and hybrid glycosaminoglycan polymers and methods of making and using same | BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA, THE | 2006-08-24 | — | — | US | disclosed |
| US-20060183203-A1 | Polymer grafting by polysaccharide synthases | DEANGELIS PAUL L | 2006-08-17 | — | — | US | disclosed |
| US-7060469-B2 | Polymer grafting by polysaccharide synthases | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2006-06-13 | — | — | US | disclosed |
| US-20060116348-A1 | Polymer grafting by polysaccharide synthases | DEANGELIS PAUL L | 2006-06-01 | — | — | US | disclosed |
| US-20050124046-A1 | Polymer grafting by polysaccharide synthases | DEANGELIS PAUL L (US) | 2005-06-09 | — | — | US | disclosed |
| US-20040132143-A1 | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same | BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA, THE | 2004-07-08 | — | — | US | disclosed |
| US-20030077763-A1 | Polymer grafting by polysaccharide synthases | DEANGELIS PAUL L (US) | 2003-04-24 | — | — | US | disclosed |
| US-6444447-B1 | USING THE HYALURONATE SYNTHASE FROM PASTEURELLA MULTOCIDA FOR GRAFTING, COATING FOR BIOMATERIALS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2002-09-03 | — | — | US | disclosed |
| EP-1129209-A2 | POLYMER GRAFTING BY POLYSACCHARIDE SYNTHASES | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027437-A2 | POLYMER GRAFTING BY POLYSACCHARIDE SYNTHASES | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2000-05-18 | — | — | WO | disclosed |