Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.38 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15998851 | 0.91 | ALDH1A1 (0.47) | ALDH1A1OPRM1EPHX2BLMCYP1A2 | |
| SCHEMBL13131126 | 0.88 | HSD11B1 (0.51) | ALDH1A1OPRM1HSD11B1USP2CYP3A4 | |
| SCHEMBL25870846 | 0.86 | CYP1A2 (0.44) | ALDH1A1OPRM1EPHX2BLMCYP1A2 | |
| SCHEMBL25703446 | 0.83 | ALDH1A1 (0.53) | ALDH1A1OPRM1EPHX2BLMCYP1A2 | |
| SCHEMBL26868241 | 0.82 | CYP1A2 (0.54) | ALDH1A1CYP1A2CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL18711512 | 0.81 | ALDH1A1 (0.55) | ALDH1A1OPRM1EPHX2CYP1A2HSD11B1 | |
| SCHEMBL21765702 | 0.81 | OPRM1 (0.53) | ALDH1A1OPRM1BLMCYP1A2HSD11B1 | |
| SCHEMBL15431457 | 0.80 | OPRM1 (0.41) | ALDH1A1OPRM1EPHX2BLMCYP1A2 | |
| SCHEMBL26854533 | 0.80 | CHRNB2 (0.44) | ALDH1A1OPRM1EPHX2BLMCYP1A2 | |
| SCHEMBL15998890 | 0.79 | OPRM1 (0.51) | ALDH1A1OPRM1HSD11B1USP2CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10906888-B2 | Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme | PFIZER INC. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20190315715-A1 | NOVEL PYRIMIDINE CARBOXAMIDES AS INHIBITORS OF VANIN-1 ENZYME | PFIZER INC. (US) | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315715-A1 | NOVEL PYRIMIDINE CARBOXAMIDES AS INHIBITORS OF VANIN-1 ENZYME | VNN1, DPYD, MVD | ALDH1A1 416/4885OPRM1 1062/4885EPHX2 1659/4885 |
| US-10906888-B2 | Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme | VNN1, DPYD, MVD | ALDH1A1 405/4885OPRM1 843/4885EPHX2 1772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.