Sugi Predict

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SCHEMBL2148165

SCHEMBL2148165

CCCCNC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 2/20 0.35
▸ HPGD P15428 1/20 0.35
▸ HTT P42858 3/20 0.35
▸ GAA P10253 1/20 0.35
▸ LMNA P02545 3/20 0.35
▸ NPC1 O15118 2/20 0.35
▸ TP53 P04637 2/20 0.35
▸ RAB9A P51151 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ HIF1A Q16665 1/20 0.35
▸ KCNA3 P22001 2/20 0.34
▸ TSHR P16473 1/20 0.34
▸ CNR2 P34972 1/20 0.34
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ ALOX12 P18054 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ THRB P10828 1/20 0.33
▸ RECQL P46063 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15272052 0.92 HTT (0.34) HTTGAALMNANPC1TP53
SCHEMBL15059546 0.91 TTK (0.36) LMNA
SCHEMBL15059547 0.91 TTK (0.36) LMNA
SCHEMBL740369 0.89 CA1 (0.34) LMNATP53L3MBTL1ALDH1A1ALOX12
SCHEMBL2993930 0.89 FNTA (0.33) HPGDHTTLMNANPC1TP53
SCHEMBL119374 0.89 PTGES (0.35) LMNATP53ALDH1A1ALOX12KDM4E
SCHEMBL2985606 0.88 PPARD (0.33) LMNATP53L3MBTL1ALDH1A1ALOX12
SCHEMBL20921637 0.88 KDM4E (0.32) LMNATP53L3MBTL1ALDH1A1ALOX12
SCHEMBL737408 0.88 EGLN1 (0.36) LMNARAB9AL3MBTL1ALDH1A1KDM4E
Hydrochloric Acid SCHEMBL738507 0.88 CA1 (0.33) LMNAL3MBTL1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014131837-A1 ISOXALINE DERIVATIVES FOR USE IN COTTON PLANTS SYNGENTA PARTICIPATIONS AG (CH) 2014-09-04 — — WO disclosed
US-8822502-B2 Insecticidal compounds SYNGENTA CROP PROTECTION LLC (US) 2014-09-02 — — US disclosed
US-8822502-B2 Insecticidal compounds SYNGENTA CROP PROTECTION LLC (US) 2014-09-02 — — US disclosed
EP-2331515-B1 INSCETICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2013-07-10 — — EP disclosed
EP-2331515-B1 INSCETICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2013-07-10 — — EP disclosed
US-20110166184-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION LLC (US) 2011-07-07 — — US disclosed
US-20110166184-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION LLC (US) 2011-07-07 — — US disclosed
WO-2010020521-A1 INSCETICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2010-02-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166184-A1 INSECTICIDAL COMPOUNDS ACHE, CHRM1, C1R CNR1 205/4885HPGD 2416/4885HTT 3014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.