SCHEMBL2993930

SCHEMBL2993930

CSCCNC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1C

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FNTA P49354 1/20 0.33
FNTB P49356 1/20 0.33
TP53 P04637 3/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
NPC1 O15118 2/20 0.33
HPGD P15428 1/20 0.33
NFKB1 P19838 1/20 0.33
MAPK1 P28482 1/20 0.33
RAB9A P51151 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KDM4E B2RXH2 2/20 0.33
LMNA P02545 2/20 0.33
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CYP1A2 P05177 1/20 0.31
POLB P06746 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2148165 0.89 CNR1 (0.35) TP53L3MBTL1NPC1HPGDRAB9A
SCHEMBL15059546 0.89 TTK (0.36) LMNACA1CA2ELOVL6
SCHEMBL15059547 0.89 TTK (0.36) LMNACA1CA2ELOVL6
SCHEMBL740369 0.89 CA1 (0.34) TP53L3MBTL1KDM4ELMNACA1
SCHEMBL119374 0.88 PTGES (0.35) TP53KDM4ELMNACA1CA2
SCHEMBL2985606 0.87 PPARD (0.33) TP53L3MBTL1KDM4ELMNACA1
SCHEMBL20921637 0.87 KDM4E (0.32) TP53L3MBTL1KDM4ELMNACA1
Hydrochloric Acid SCHEMBL738507 0.87 CA1 (0.33) L3MBTL1KDM4ELMNACA1CA2
SCHEMBL737408 0.87 EGLN1 (0.36) L3MBTL1RAB9AKDM4ELMNACA1
SCHEMBL2992226 0.87 HDAC4 (0.32) FNTAFNTBTP53KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3351243-A1 ANIMAL PEST CONTROL METHOD E. I. du Pont de Nemours and Company (US) 2018-07-25 EP claimed
EP-2957284-B1 ANIMAL PEST CONTROL METHOD DU PONT (US) 2018-01-17 EP claimed
EP-2182945-B1 ANIMAL PEST CONTROL METHOD DU PONT (US) 2015-08-05 EP claimed
US-20220168278-A1 LOW DOSE FLURALANER COMPOSITIONS FOR PROTECTION AGAINST PARASITIC INVERTEBRATE PEST VIRBAC (FR) 2022-06-02 US disclosed
US-11278533-B2 Animal pest control method E.I. DU PONT DE NEMOURS AND COMPANY (US) 2022-03-22 US disclosed
EP-3927341-A1 LOW DOSE FLURALANER COMPOSITIONS FOR PROTECTION AGAINST PARASITIC INVERTEBRATE PEST VIRBAC (FR) 2021-12-29 EP disclosed
WO-2020201440-A1 LOW DOSE FLURALANER COMPOSITIONS FOR PROTECTION AGAINST PARASITIC INVERTEBRATE PEST VIRBAC (FR) 2020-10-08 WO disclosed
US-20180353494-A1 ANIMAL PEST CONTROL METHOD E. I. DU PONT DE NEMOURS AND COMPANY (US) 2018-12-13 US disclosed
EP-3351243-A1 ANIMAL PEST CONTROL METHOD E. I. du Pont de Nemours and Company (US) 2018-07-25 EP disclosed
US-20160317520-A1 ANIMAL PEST CONTROL METHOD E. I. DU PONT DE NEMOURS AND COMPANY (US) 2016-11-03 US disclosed
EP-2957284-A1 ANIMAL PEST CONTROL METHOD E. I. du Pont de Nemours and Company (US) 2015-12-23 EP disclosed
US-20150272938-A2 ANIMAL PEST CONTROL METHOD E.I. DU PONT DE NEMOURS AND COMPANY (US) 2015-10-01 US disclosed
EP-2182945-B1 ANIMAL PEST CONTROL METHOD DU PONT (US) 2015-08-05 EP disclosed
US-20100173948-A1 ANIMAL PEST CONTROL METHOD E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-07-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180353494-A1 ANIMAL PEST CONTROL METHOD L3MBTL3, C3AR1, C5 FNTA 1786/4885FNTB 1200/4885TP53 4254/4885
US-11278533-B2 Animal pest control method L3MBTL3, C3AR1, C5 FNTA 1786/4885FNTB 1200/4885TP53 4254/4885
US-20150272938-A2 ANIMAL PEST CONTROL METHOD L3MBTL3, C3AR1, C5 FNTA 1786/4885FNTB 1200/4885TP53 4254/4885
US-20100173948-A1 ANIMAL PEST CONTROL METHOD L3MBTL3, C3AR1, C5 FNTA 1786/4885FNTB 1200/4885TP53 4254/4885
US-20220168278-A1 LOW DOSE FLURALANER COMPOSITIONS FOR PROTECTION AGAINST PARASITIC INVERTEBRATE PEST P2RX7, CAT, PDE8A FNTA 1679/4885FNTB 2435/4885TP53 3810/4885
US-20160317520-A1 ANIMAL PEST CONTROL METHOD L3MBTL3, C3AR1, C5 FNTA 1786/4885FNTB 1200/4885TP53 4254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.