Urea

Urea

SCHEMBL2148631

NC(=O)N=S(=O)=O.NC(N)=O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.43
LMNA P02545 1/20 0.43
OR51E2 Q9H255 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
CYP3A4 P08684 1/20 0.41
HPGD P15428 1/20 0.41
EHMT2 Q96KQ7 1/20 0.41
HSD17B10 Q99714 1/20 0.41
EHMT1 Q9H9B1 1/20 0.41
ACHE P22303 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27457813 0.96 ALDH1A1 (0.44) ALDH1A1LMNAOR51E2TDP1CYP3A4
SCHEMBL16454 0.96
SCHEMBL30385793 0.93
Ammonia Solution, Strong SCHEMBL17685472 0.93
Water SCHEMBL27176182 0.93
SCHEMBL6295419 0.93
SCHEMBL3949253 0.93
SCHEMBL1571702 0.93
Phosphine SCHEMBL21586379 0.93
Hydrogen Sulfide SCHEMBL28213513 0.93

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2152073-B1 HERBICIDE COMPOSITIONS SYNGENTA LTD (GB) 2015-04-15 EP claimed
US-20110166023-A1 HERBICIDE COMPOSITION SYNGENTA LIMITED (GB) 2011-07-07 US claimed
CN-101795560-A Herbicide compositions SYNGENTA LTD 2010-08-04 CN claimed
EP-2152073-A1 HERBICIDE COMPOSITIONS Syngenta Limited (GB) 2010-02-17 EP claimed
WO-2008142391-A1 HERBICIDE COMPOSITIONS SYNGENTA LIMITED (GB) 2008-11-27 WO claimed
CN-107252420-A The pharmaceutical composition of rosuvastatin calcium 阿斯利康(英国)有限公司 2017-10-17 CN disclosed
EP-1812429-A2 SUBSTITUTED 2H-1,3-BENZOXAZIN-4(3H)-ONES Portola Pharmaceuticals, Inc. (US) 2007-08-01 EP disclosed
US-7205296-B2 Substituted 2H-1,3-benzoxazin-4(3H)-ones PORTOLA PHARMACEUTICALS, INC. (US) 2007-04-17 US disclosed
WO-2006039212-A2 SUBSTITUTED 2H-1,3-BENZOXAZIN-4(3H)-ONES PORTOLA PHARMACEUTICALS, INC. (US) 2006-04-13 WO disclosed
US-20060069093-A1 Substituted 2H-1,3-benzoxazin-4(3H)-ones PORTOLA PHARMACEUTICALS, INC. (US) 2006-03-30 US disclosed
WO-2005105044-A1 PROCESS FOR MAKING INCLUSION COMPLEX OF SULFONYLUREAS HAVING IMPROVED AQUEOUS SOLUBILITY RANBAXY LABORATORIES LIMITED (IN) 2005-11-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060069093-A1 Substituted 2H-1,3-benzoxazin-4(3H)-ones TBXAS1, TBXA2R, SERPINC1 ALDH1A1 704/4885LMNA 1495/4885OR51E2 4471/4885
US-20110166023-A1 HERBICIDE COMPOSITION HTT, DDT, HDHD5 ALDH1A1 328/4885LMNA 2675/4885OR51E2 2661/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.