SCHEMBL2149663

SCHEMBL2149663

Cn1c(C(F)(F)F)cc(=O)n(-c2cc(N)c(Cl)cc2F)c1=O

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 3/20 0.30
BCAT1 P54687 3/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7682149 0.90 TP53 (0.35) BCAT2BCAT1
SCHEMBL10695874 0.89 BCAT1 (0.34) BCAT2BCAT1
SCHEMBL10695876 0.89 BCAT1 (0.34) BCAT2BCAT1
SCHEMBL10697818 0.86 GAA (0.34) BCAT2BCAT1
SCHEMBL38662770 0.86 GAA (0.34) BCAT2BCAT1
SCHEMBL2149670 0.86 BCAT2 (0.31) BCAT2BCAT1
SCHEMBL29452606 0.86 BCAT2 (0.31) BCAT2BCAT1
SCHEMBL8896889 0.86 ATAD2 (0.39) BCAT2BCAT1
SCHEMBL1400120 0.85 GRM4 (0.32) BCAT2BCAT1
SCHEMBL3896362 0.85 JAK2 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2343284-B1 URACIL-BASED COMPOUNDS, AND HERBICIDES COMPRISING SAME KOREA RES INST CHEM TECH (KR) 2014-12-03 EP disclosed
US-8193198-B2 Uracil compounds and a herbicide comprising the same KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2012-06-05 US disclosed
US-20110224083-A1 URACIL COMPOUNDS AND A HERBICIDE COMPRISING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2011-09-15 US disclosed
EP-2343284-A2 URACIL-BASED COMPOUNDS, AND HERBICIDES COMPRISING SAME Korea Research Institute Of Chemical Technology (KR) 2011-07-13 EP disclosed
US-7169952-B2 Process to prepare sulfonamides FMC CORPORATION (US) 2007-01-30 US disclosed
EP-1122244-B1 Uracil compounds and their use SUMITOMO CHEMICAL CO (JP) 2004-09-29 EP disclosed
US-20030236437-A1 Process to prepare sulfonamides FMC CORPORATION 2003-12-25 US disclosed
US-6537948-B1 Have a wide range of herbicidal spectrum, and causes no phytotoxicity on crops SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-25 US disclosed
US-20020137929-A1 1 - (3-heterocyclylphenyl) isothiourea, -isourea, -guanidine and -amidine herbicidal agents INTELLECTUAL PROPERTY DEPARTMENT, BASF AKTIENGESELLSCHAFT (DE) 2002-09-26 US disclosed
US-6352958-B1 PRE- AND POST-EMERGENCE HERBICIDES FMC CORPORATION 2002-03-05 US disclosed
WO-1997008170-A1 HERBICIDAL 3-(SUBSTITUTED BENZOXAZOL-7-YL) AND 3-(SUBSTITUTED BENZOTHIAZOL-7-YL)-1-SUBSTITUTED-6-TRIFLUOROMETHYL-2,4-(1H,3H)PYRIMIDINEDIONES FMC CORPORATION (US) 1997-03-06 WO disclosed
US-5356863-A Herbicides NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1994-10-18 US disclosed
US-5281574-A Herbicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-01-25 US disclosed
EP-0563384-A1 URACIL DERIVATIVE NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1993-10-06 EP disclosed
EP-0540023-A1 Uracil derivatives and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-05-05 EP disclosed
US-5154755-A Uracil derivatives and herbicides containing the same as active ingredient NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1992-10-13 US disclosed
EP-0489480-A1 Uracil derivatives and herbicides containing the same as active ingredient NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1992-06-10 EP disclosed
US-5084084-A Uracil and thiouracil derivatives NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1992-01-28 US disclosed
US-4859229-A HERBICIDES HOFFMANN-LA ROCHE INC. (US) 1989-08-22 US disclosed
EP-0255047-A1 3-Aryl uraciles and their use as herbicides CIBA-GEIGY AG (CH) 1988-02-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110224083-A1 URACIL COMPOUNDS AND A HERBICIDE COMPRISING THE SAME UNG, DPYD, DDX41 BCAT2 681/4885BCAT1 820/4885
US-20030236437-A1 Process to prepare sulfonamides SULT2A1, SULT1A1, SRM BCAT2 358/4885BCAT1 847/4885
US-20020137929-A1 1 - (3-heterocyclylphenyl) isothiourea, -isourea, -guanidine and -amidine herbicidal agents IMPDH1, GANC, DDT BCAT2 1658/4885BCAT1 1438/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.