Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.58 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 4/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.49 |
| ▸ | DDX3X | O00571 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1970882 | 0.85 | CRHBP (0.72) | CRHBPCRHR2KMT2AMEN1TSHR | |
| SCHEMBL31402302 | 0.81 | KMT2A (0.59) | KMT2AMEN1TSHRCA2CA12 | |
| SCHEMBL21497038 | 0.81 | KMT2A (0.59) | KMT2AMEN1TSHRCA2CA12 | |
| SCHEMBL21893366 | 0.80 | CA2 (0.62) | CRHBPCRHR2KMT2AMEN1TSHR | |
| SCHEMBL3070697 | 0.76 | CA2 (0.73) | CRHBPCRHR2KMT2ANFKBIARELA | |
| SCHEMBL29498571 | 0.75 | TSHR (0.51) | KMT2AMEN1TSHRCA2CA1 | |
| SCHEMBL19994887 | 0.75 | TSHR (0.51) | KMT2AMEN1TSHRCA2CA1 | |
| SCHEMBL11932398 | 0.75 | CRHBP (0.61) | CRHBPCRHR2KMT2AMEN1TSHR | |
| SCHEMBL11872858 | 0.75 | DDX3X (0.71) | CRHBPCRHR2KMT2AMEN1TSHR | |
| SCHEMBL163325 | 0.74 | RECQL (0.69) | CRHBPCRHR2KMT2AMEN1NFKBIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236044-B2 | Selective inhibitors of 12(S)-lipoxygenase (12-LOX) and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210147348-A1 | SELECTIVE INHIBITORS OF 12(S)- LIPOXYGENASE (12-LOX) AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2021-05-20 | — | — | US | disclosed |
| CN-112566898-A | Selective inhibitors of 12(S) -lipoxygenase (12-LOX) and methods of use thereof | 密歇根大学董事会 | 2021-03-26 | — | — | CN | disclosed |
| EP-3781548-A1 | SELECTIVE INHIBITORS OF 12(S)-LIPOXYGENASE (12-LOX) AND METHODS FOR USE OF THE SAME | The Regents Of The University Of Michigan (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204375-A1 | SELECTIVE INHIBITORS OF 12(S)-LIPOXYGENASE (12-LOX) AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11236044-B2 | Selective inhibitors of 12(S)-lipoxygenase (12-LOX) and methods for use of the same | ALOX12, LOX, ALOX15 | CRHBP 3927/4885CRHR2 3549/4885KMT2A 3523/4885 |
| US-20210147348-A1 | SELECTIVE INHIBITORS OF 12(S)- LIPOXYGENASE (12-LOX) AND METHODS FOR USE OF THE SAME | ALOX12, LOX, ALOX15 | CRHBP 3927/4885CRHR2 3549/4885KMT2A 3523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.