Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL21522569

O=C(O)C(F)(F)F.SCCS

nearest known ligand 0.36

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
FOLH1 Q04609 1/20 0.35
ACLY P53396 2/20 0.35
ACE P12821 1/20 0.33
THRB P10828 1/20 0.33
CES1 P23141 2/20 0.32
POLB P06746 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CA2 P00918 1/20 0.32
TSHR P16473 2/20 0.32
TP53 P04637 1/20 0.32
TET2 Q6N021 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL11412719 0.88 ACLY (0.32) ALDH1A1L3MBTL1FOLH1ACLYACE
Trifluoroacetic Acid SCHEMBL29736079 0.85 TSHR (0.44) ALDH1A1THRBSMN1; SMN2CA2TSHR
Trifluoroacetic Acid SCHEMBL5470574 0.84 FAAH (0.39) ALDH1A1L3MBTL1ACLYCES1TSHR
Trifluoroacetic Acid SCHEMBL7814389 0.82 ALDH1A1 (0.44) ALDH1A1L3MBTL1ACLYTHRBCES1
Trifluoroacetic Acid SCHEMBL30657022 0.82
Trifluoroacetic Acid SCHEMBL2484766 0.82 ALDH1A1 (0.44) ALDH1A1L3MBTL1ACLYTHRBCES1
Trifluoroacetic Acid SCHEMBL474 0.82
Trifluoroacetic Acid SCHEMBL4598430 0.82
Trifluoroacetic Acid SCHEMBL21046071 0.79 DPP8 (0.31)
Trifluoroacetic Acid SCHEMBL28235039 0.79 ALDH1A1 (0.38) ALDH1A1L3MBTL1ACLYTHRBCES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11560402-B2 Method for cleavage of solid phase-bound peptides from the solid phase SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2023-01-24 US disclosed
EP-3774838-B1 LIXISENATIDE SYNTHESIS WITH CAPPING SANOFI AVENTIS DEUTSCHLAND (DE) 2022-08-10 EP disclosed
US-11028123-B2 Capping of unprotected amino groups during peptide synthesis SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2021-06-08 US disclosed
US-20190330266-A1 METHOD FOR CLEAVAGE OF SOLID PHASE-BOUND PEPTIDES FROM THE SOLID PHASE SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2019-10-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11560402-B2 Method for cleavage of solid phase-bound peptides from the solid phase VIP, PTMS, CTRC ALDH1A1 4161/4885L3MBTL1 1923/4885FOLH1 159/4885
US-20190330266-A1 METHOD FOR CLEAVAGE OF SOLID PHASE-BOUND PEPTIDES FROM THE SOLID PHASE VIP, PTMS, CTRC ALDH1A1 4161/4885L3MBTL1 1923/4885FOLH1 159/4885
US-11028123-B2 Capping of unprotected amino groups during peptide synthesis RNGTT, ANPEP, DNPEP ALDH1A1 4398/4885L3MBTL1 771/4885FOLH1 577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.