Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.35 |
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2152345 | 0.83 | HRH4 (0.41) | ACHENPC1 | |
| SCHEMBL2152350 | 0.83 | PBRM1 (0.35) | PNMTKDM1AACHENPC1 | |
| SCHEMBL31006601 | 0.82 | PNMT (0.48) | PNMTDPP4KDM1APTGS2 | |
| SCHEMBL2152425 | 0.80 | SSTR4 (0.36) | — | |
| SCHEMBL2152303 | 0.76 | EZH2 (0.30) | — | |
| SCHEMBL8688431 | 0.74 | TDP1 (0.51) | PNMTNPC1ABCB1 | |
| SCHEMBL8899294 | 0.71 | PNMT (0.37) | PNMTDPP4KDM1AABCB1PTGS2 | |
| SCHEMBL10440186 | 0.69 | PNMT (0.33) | PNMTABCB1PTGS2 | |
| SCHEMBL9358376 | 0.69 | PNMT (0.36) | PNMTDPP4KDM1AABCB1PTGS2 | |
| SCHEMBL2152471 | 0.69 | POLB (0.45) | ABCB1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125766-B1 | BENZOFURAN ANTIPARASITIC AGENTS | PFIZER LTD (GB) | 2011-07-06 | — | — | EP | disclosed |
| US-20100035980-A1 | ANTIPARASITIC AGENTS | PFIZER LIMITED (GB) | 2010-02-11 | — | — | US | disclosed |
| US-7622500-B2 | Antiparasitic agents | PFIZER LIMITED (GB) | 2009-11-24 | — | — | US | disclosed |
| US-20080200540-A1 | ANTIPARASITIC AGENTS | PFIZER LIMITED (GB) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035980-A1 | ANTIPARASITIC AGENTS | ACHE, MPO, ABCB11 | PNMT 86/4885DPP4 699/4885KDM1A 4038/4885 |
| US-20080200540-A1 | ANTIPARASITIC AGENTS | ACHE, MPO, ABCB11 | PNMT 86/4885DPP4 699/4885KDM1A 4038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.