Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 7/20 | 0.37 |
| ▸ | TYMP | P19971 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TK2 | O00142 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2685934 | 1.00 | TK1 (0.37) | TK1TYMPHPGDTK2 | |
| SCHEMBL9328006 | 1.00 | TK1 (0.37) | TK1TYMPHPGDTK2 | |
| SCHEMBL2153594 | 0.91 | TK1 (0.39) | TK1TYMPHPGD | |
| SCHEMBL2161843 | 0.91 | TK1 (0.39) | TK1TYMPHPGD | |
| SCHEMBL8642049 | 0.82 | TK1 (0.39) | TK1TYMPHPGDTK2 | |
| SCHEMBL6931032 | 0.80 | TK1 (0.38) | TK1TYMPHPGDTK2 | |
| SCHEMBL6513732 | 0.80 | TK1 (0.38) | TK1TYMPHPGDTK2 | |
| SCHEMBL6924139 | 0.80 | SLC9A1 (0.40) | — | |
| SCHEMBL6931025 | 0.80 | SLC9A1 (0.40) | — | |
| SCHEMBL2153131 | 0.80 | TK1 (0.37) | TK1TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115136-A1 | PNA DIAGNOSTIC USE | PNA Patent Owners (a/k/a CIG) (US) | 2012-05-10 | — | — | US | disclosed |
| EP-1074559-B1 | Peptide nucleic acids | BUCHARDT OLE (DK) | 2011-07-06 | — | — | EP | disclosed |
| US-7378485-B2 | Peptide nucleic acids with polyamide-containing backbones | BUCHARDT OLE | 2008-05-27 | — | — | US | disclosed |
| US-20060046255-A1 | Use of nucleic acid analogues in diagnostics and analytical procedures | BUCHARDT OLE | 2006-03-02 | — | — | US | disclosed |
| EP-0960121-B1 | PEPTIDE NUCLEIC ACIDS HAVING ENHANCED BINDING AFFINITY, SEQUENCE SPECIFICITY AND SOLUBILITY | BUCHARDT DORTE (DK) | 2005-11-30 | — | — | EP | disclosed |
| US-20050009041-A1 | Peptide nucleic acids and synthetic procedures therefor | BUCHARDT OLE (DK) | 2005-01-13 | — | — | US | disclosed |
| EP-1411063-A1 | Peptide nucleic acids | BUCHARDT, Ole (DK) | 2004-04-21 | — | — | EP | disclosed |
| US-6713602-B1 | COMPOUNDS THAT ARE NOT POLYNUCLEOTIDES YET WHICH BIND TO COMPLEMENTARY DNA AND RNA STRANDS MORE STRONGLY THE CORRESPONDING DNA | BUCHARDT OLE (DK) | 2004-03-30 | — | — | US | disclosed |
| US-6710163-B1 | COMPOUNDS THAT BIND SINGLE-STRANDED DNA AND RNA STRANDS TO FORM STABLE HYBRIDS; BIND COMPLEMENTARY SINGLE-STRANDED DNA AND RNA STRANDS MORE STRONGLY THAN CORRESPONDING DNA | BUCHARDT OLE (DK) | 2004-03-23 | — | — | US | disclosed |
| US-6710164-B1 | COMPRISING AT LEAST ONE C1-C8 ALKYLAMINE SIDE CHAIN | NIELSEN PETER E (DK) | 2004-03-23 | — | — | US | disclosed |
| EP-1074559-A1 | Peptide nucleic acids | BUCHARDT, Ole (DK) | 2001-02-07 | — | — | EP | disclosed |
| US-5786461-A | Peptide nucleic acids having amino acid side chains | BUCHARDT OLE (DK) | 1998-07-28 | — | — | US | disclosed |
| US-5736336-A | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility | BUCHARDT OLE (DK) | 1998-04-07 | — | — | US | disclosed |
| US-5719262-A | BIND COMPLEMENTARY DNA AND RNA STRANDS MORE STRONGLY | BUCHARDT OLE (DK) | 1998-02-17 | — | — | US | disclosed |
| US-5714331-A | INCORPORATING AN AMINOALKYL SIDE CHAIN INTO THE PNA'S WHICH BIND TO COMPLEMENTARY NUCLEOBASE SEQUENCES MORE TIGHTLY TO FORM ?DUPLEXES?; VIRICIDES; ANTICARCINOGENIC AGENTS; ENZYME INHIBITORS | EXXON CHEMICAL PATENT INC. | 1998-02-03 | — | — | US | disclosed |
| EP-0586618-B1 | THE USE OF NUCLEIC ACID ANALOGUES IN DIAGNOSTICS AND ANALYTICAL PROCEDURES | BUCHARDT DORTE (DK) | 1997-07-16 | — | — | EP | disclosed |
| US-5539082-A | Peptide nucleic acids | NIELSEN PETER E (DK) | 1996-07-23 | — | — | US | disclosed |
| EP-0586618-A1 | THE USE OF NUCLEIC ACID ANALOGUES IN DIAGNOSTICS AND ANALYTICAL PROCEDURES. | BUCHARDT OLE (DK) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992020703-A1 | THE USE OF NUCLEIC ACID ANALOGUES IN DIAGNOSTICS AND ANALYTICAL PROCEDURES | BUCHARDT OLE (DK) | 1992-11-26 | — | — | WO | disclosed |
| WO-1992020702-A1 | PEPTIDE NUCLEIC ACIDS | BUCHARDT OLE (DK) | 1992-11-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115136-A1 | PNA DIAGNOSTIC USE | RNASE1, NCL, PABPC4 | TK1 1839/4885TYMP 423/4885HPGD 3175/4885 |
| US-20050009041-A1 | Peptide nucleic acids and synthetic procedures therefor | POLRMT, CPSF7, RNGTT | TK1 290/4885TYMP 187/4885HPGD 4345/4885 |
| US-20060046255-A1 | Use of nucleic acid analogues in diagnostics and analytical procedures | ADAR, POLRMT, POLI | TK1 261/4885TYMP 48/4885HPGD 2841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.