Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenyl Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.70 |
| ▸ | FFAR1 | O14842 | 10/20 | 0.66 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenyl Propionic Acid SCHEMBL27907310 | 0.86 | KEAP1 (0.86) | KEAP1FFAR1FFAR4HDAC2HDAC8 | |
| Phenyl Propionic Acid SCHEMBL9367567 | 0.84 | KEAP1 (0.83) | KEAP1FFAR1FFAR4HDAC2HDAC8 | |
| Phenyl Propionic Acid SCHEMBL235064 | 0.84 | KEAP1 (1.00) | KEAP1FFAR1FFAR4HDAC2HDAC8 | |
| Phenyl Propionic Acid SCHEMBL27523271 | 0.84 | KEAP1 (1.00) | KEAP1FFAR1FFAR4HDAC2HDAC8 | |
| Phenyl Propionic Acid SCHEMBL13618844 | 0.84 | KEAP1 (1.00) | KEAP1FFAR1FFAR4HDAC2HDAC8 | |
| Phenyl Propionic Acid SCHEMBL29619843 | 0.84 | KEAP1 (1.00) | KEAP1FFAR1FFAR4HDAC2HDAC8 | |
| Phenyl Propionic Acid SCHEMBL3419 | 0.84 | KEAP1 (1.00) | KEAP1FFAR1FFAR4HDAC2HDAC8 | |
| Phenylethyl Alcohol SCHEMBL27638060 | 0.82 | TDP1 (0.73) | SMN1; SMN2MAPT | |
| SCHEMBL357594 | 0.82 | SIGMAR1 (0.65) | MAPT | |
| Phenyl Propionic Acid SCHEMBL9175295 | 0.82 | KEAP1 (0.95) | KEAP1FFAR1FFAR4HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1753968-B | Antioxidant composition and external composition | MITSUBISHI CORP | 2010-04-28 | — | — | CN | claimed |
| CN-1753968-A | Antioxidant composition and external composition | MITSUBISHI CORP (JP) | 2006-03-29 | — | — | CN | claimed |
| EP-3689897-A1 | A CNP CYCLIC PEPTIDE AND A MEDICAMENT, EXTERNAL PREPARATION AND COSMETIC CONTAINING THE CYCLIC PEPTIDE | Igisu Co., Ltd. (JP) | 2020-08-05 | — | — | EP | disclosed |
| US-20190119325-A1 | CNP CYCLIC PEPTIDE, AND MEDICINE, EXTERNAL PREPARATION AND COSMETIC EACH CONTAINING SAID CYCLIC PEPTIDE | IGISU CO., LTD. (JP) | 2019-04-25 | — | — | US | disclosed |
| CN-109348717-A | CNP cyclic peptide, and drug, external preparation and cosmetic containing the same | IGISU株式会社 | 2019-02-15 | — | — | CN | disclosed |
| CN-105616179-B | A kind of active factors COAWA of activation affinity interaction and its preparation and application | 上海尚雪实业有限公司 | 2018-11-06 | — | — | CN | disclosed |
| EP-3330280-A1 | CNP CYCLIC PEPTIDE, AND MEDICINE, EXTERNAL PREPARATION AND COSMETIC EACH CONTAINING SAID CYCLIC PEPTIDE | Igisu Co., Ltd. (JP) | 2018-06-06 | — | — | EP | disclosed |
| CN-107709352-A | Cyclic peptide and medicine, external preparation and cosmetics containing the cyclic peptide | IGISU株式会社 | 2018-02-16 | — | — | CN | disclosed |
| CN-105848634-A | Oil-in-water emulsion cosmetic for skin | 株式会社高丝 | 2016-08-10 | — | — | CN | disclosed |
| CN-105616179-A | Active factor COAWA for activating affinity interaction and preparation and application thereof | SHANGHAI SHANGXUE IND CO LTD | 2016-06-01 | — | — | CN | disclosed |
| CN-105209007-A | Oil-in-water sunscreen cosmetic | KAO CORP | 2015-12-30 | — | — | CN | disclosed |
| CN-1968690-A | Inflammation inhibitor containing zinc salt of acylamino acid | AJINOMOTO KK (JP) | 2007-05-23 | — | — | CN | disclosed |
| CN-1863543-A | Dietetic composition | ORYZA OIL & FAT CHEM (JP) | 2006-11-15 | — | — | CN | disclosed |
| CN-1761449-A | Cosmetic preparation | KANEBO COSMETICS INC (JP) | 2006-04-19 | — | — | CN | disclosed |
| CN-1753968-A | Antioxidant composition and external composition | MITSUBISHI CORP (JP) | 2006-03-29 | — | — | CN | disclosed |
| CN-1706378-A | Composition for treating inflammation which contains zinc pyrrolidonecarboxylate | AJINOMOTO KK (JP) | 2005-12-14 | — | — | CN | disclosed |
| CN-1213716-C | Cosmetic preparation | KANEBO COSMETICS LTD (JP) | 2005-08-10 | — | — | CN | disclosed |
| CN-1382033-A | Comestios | KANEBO LTD (JP) | 2002-11-27 | — | — | CN | disclosed |
| US-6132743-A | COATING A ZINC OXIDE POWDER WITH AT LEAST ONE SILICONE COMPOUND IN A NONGASEOUS STATE AND FIRING THE COATED ZINC OXIDE POWDER IN AN OXIDIZING ATMOSPHERE AT A TEMPERATURE OF 600 TO 950 DEGREES C. | KANEBO, LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0957139-A1 | ZINC OXIDE POWDER WITH SUPPRESSED ACTIVITY AND COSMETIC PREPARATION | KANEBO LTD. (JP) | 1999-11-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190119325-A1 | CNP CYCLIC PEPTIDE, AND MEDICINE, EXTERNAL PREPARATION AND COSMETIC EACH CONTAINING SAID CYCLIC PEPTIDE | NPR1, CNP, NPR3 | KEAP1 2975/4885FFAR1 789/4885FFAR4 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.