Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Stearic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.59 |
| ▸ | PPARG | P37231 | 7/20 | 0.59 |
| ▸ | PPARD | Q03181 | 7/20 | 0.59 |
| ▸ | PPARA | Q07869 | 7/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.59 |
| ▸ | FABP4 | P15090 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TLR2 | O60603 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.59 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Behenic Acid SCHEMBL16107136 | 1.00 | GPR84 (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| Stearic Acid SCHEMBL16107494 | 0.88 | GPR84 (0.57) | GPR84PPARGPPARDPPARAHDAC11 | |
| Stearic Acid SCHEMBL2153245 | 0.88 | GPR84 (0.61) | GPR84PPARGPPARDPPARAHDAC11 | |
| Stearic Acid SCHEMBL16107258 | 0.84 | GPR84 (0.61) | GPR84PPARGPPARDPPARAHDAC11 | |
| Behenic Acid SCHEMBL16107269 | 0.84 | GPR84 (0.61) | GPR84PPARGPPARDPPARAHDAC11 | |
| N,N-Diethylstearamide SCHEMBL28101660 | 0.84 | LMNA (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| N,N-Diethylstearamide SCHEMBL28101636 | 0.84 | LMNA (0.59) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL28052623 | 0.83 | LMNA (0.70) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL3348260 | 0.83 | LMNA (0.70) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL23646903 | 0.81 | LMNA (0.73) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2786738-B1 | HAIR TREATMENT AGENT COMPOSITION | KAO CORP (JP) | 2015-07-22 | — | — | EP | disclosed |
| US-9023330-B2 | Hair treatment composition | KAO CORPORATION (JP) | 2015-05-05 | — | — | US | disclosed |
| EP-2786738-A1 | HAIR TREATMENT AGENT COMPOSITION | Kao Corporation (JP) | 2014-10-08 | — | — | EP | disclosed |
| US-20140290688-A1 | HAIR TREATMENT COMPOSITION | KAO CORPORATION (JP) | 2014-10-02 | — | — | US | disclosed |
| US-20130023591-A1 | Phenyl-Containing Organopolysiloxane Composition, Raw Cosmetic Material, and Glossy Cosmetic Material | DOW CORNING TORAY CO., LTD. (JP) | 2013-01-24 | — | — | US | disclosed |
| EP-2519587-A1 | PHENYL-CONTAINING ORGANOPOLYSILOXANE COMPOSITION, RAW COSMETIC MATERIAL, AND GLOSSY COSMETIC MATERIAL | Dow Corning Toray Co., Ltd. (JP) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011081218-A1 | PHENYL-CONTAINING ORGANOPOLYSILOXANE COMPOSITION, RAW COSMETIC MATERIAL, AND GLOSSY COSMETIC MATERIAL | DOW CORNING TORAY CO., LTD. (JP) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140290688-A1 | HAIR TREATMENT COMPOSITION | APOB, PLIN3, AGK | GPR84 902/4885PPARG 345/4885PPARD 918/4885 |
| US-20130023591-A1 | Phenyl-Containing Organopolysiloxane Composition, Raw Cosmetic Material, and Glossy Cosmetic Material | MITF, XPA, FANCI | GPR84 701/4885PPARG 2286/4885PPARD 3143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.