Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
| ▸ | THPO | P40225 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | HBB | P68871 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.53 |
| ▸ | DPP4 | P27487 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30852235 | 0.88 | LMNA (0.59) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL23414481 | 0.88 | LMNA (0.59) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL6395695 | 0.87 | LMNA (0.58) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL873210 | 0.87 | LMNA (0.58) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL27826042 | 0.87 | LMNA (0.58) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL8185392 | 0.87 | LMNA (0.58) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL8185399 | 0.87 | LMNA (0.58) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL1979500 | 0.87 | LMNA (0.58) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL6393071 | 0.87 | TP53 (0.58) | LMNATP53GMNNALDH1A1NFKB1 | |
| SCHEMBL28364179 | 0.86 | TAS1R3 (0.61) | ADORA1SMN1; SMN2NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11597924-B2 | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use | EDITAS MEDICINE, INC. (US) | 2023-03-07 | — | — | US | disclosed |
| US-20190345490-A1 | GENOME EDITING SYSTEMS COMPRISING REPAIR-MODULATING ENZYME MOLECULES AND METHODS OF THEIR USE | EDITAS MEDICINE, INC. | 2019-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190345490-A1 | GENOME EDITING SYSTEMS COMPRISING REPAIR-MODULATING ENZYME MOLECULES AND METHODS OF THEIR USE | DCLRE1B, MPG, FEN1 | LMNA 1719/4885TP53 1504/4885GMNN 523/4885 |
| US-11597924-B2 | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use | DCLRE1B, MPG, FEN1 | LMNA 1719/4885TP53 1504/4885GMNN 523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.