Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 3/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | EEF2K | O00418 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20474625 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TDP1PTGS1PTGS2HTT | |
| SCHEMBL29799492 | 0.78 | ESR1 (0.39) | DRD2MMP13 | |
| SCHEMBL21556045 | 0.75 | ALDH1A1 (0.50) | ALDH1A1PTGS1PTGS2HTTTSHR | |
| SCHEMBL21556099 | 0.74 | ALDH1A1 (0.48) | ALDH1A1PTGS1PTGS2HTTTSHR | |
| SCHEMBL21556048 | 0.73 | CA12 (0.32) | ALDH1A1HSD17B10TDP1TSHRKMT2A | |
| SCHEMBL20474622 | 0.72 | HSPB1 (0.47) | ALDH1A1HSD17B10PTGS2NPC1RAB9A | |
| SCHEMBL67837 | 0.71 | PKM (0.67) | ALDH1A1HSD17B10TDP1PKMPTGS2 | |
| SCHEMBL6108870 | 0.71 | PKM (0.67) | ALDH1A1HSD17B10TDP1PKMPTGS2 | |
| SCHEMBL9720036 | 0.71 | HTT (0.58) | ALDH1A1HSD17B10TDP1PKMNPC1 | |
| SCHEMBL433497 | 0.71 | HTT (0.58) | ALDH1A1HSD17B10TDP1PKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472386-B2 | Bile acid derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2019-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472386-B2 | Bile acid derivatives as FXR agonists and methods of use thereof | NR1H4, GPBAR1, SLC10A1 | ALDH1A1 1993/4885HSD17B10 198/4885TDP1 2842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.