Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179797 | 1.00 | AOC3 (0.47) | AOC3L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL12027335 | 1.00 | AOC3 (0.47) | AOC3L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL12027339 | 1.00 | AOC3 (0.47) | AOC3L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL12027336 | 1.00 | AOC3 (0.47) | AOC3L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL14683147 | 0.89 | L3MBTL1 (0.47) | AOC3L3MBTL1ACHEMTNR1AMTNR1B | |
| SCHEMBL14683149 | 0.88 | L3MBTL1 (0.46) | AOC3L3MBTL1TDP1KDM4EALDH1A1 | |
| SCHEMBL14683148 | 0.87 | L3MBTL1 (0.45) | AOC3L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL14683145 | 0.85 | AOC3 (0.48) | AOC3L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL18427515 | 0.85 | AOC3 (0.48) | AOC3L3MBTL1TDP1MEN1KMT2A | |
| SCHEMBL15474063 | 0.85 | CYP2D6 (0.55) | KDM4EALDH1A1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850198-B2 | Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| US-9850198-B2 | Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-12-26 | — | — | US | disclosed |
| US-20170233330-A1 | Process for the preparation of 3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]-phenol | SANDOZ AG (CH) | 2017-08-17 | — | — | US | disclosed |
| EP-2792668-B1 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-05-31 | — | — | EP | disclosed |
| EP-2519100-B1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | MAPI PHARMA LTD (IL) | 2017-03-15 | — | — | EP | disclosed |
| EP-2666765-B1 | Process for the preparation of substituted 3-(1-amino-2-methyl-pentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2017-01-04 | — | — | EP | disclosed |
| US-20160257640-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2016-09-08 | — | — | US | disclosed |
| US-20160257640-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2016-09-08 | — | — | US | disclosed |
| US-9388119-B2 | Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2016-07-12 | — | — | US | disclosed |
| US-9388119-B2 | Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds | GRUENENTHAL GMBH (DE) | 2016-07-12 | — | — | US | disclosed |
| US-8669399-B2 | Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds | Grünenthal GmbH (DE) | 2014-03-11 | — | — | US | disclosed |
| US-20140046074-A1 | Substituted n-pentanamide compounds, preparation method and the use thereof | TOPHARMAN SHANGHAI CO., LTD. (CN) | 2014-02-13 | — | — | US | disclosed |
| US-8410176-B2 | Intermediate compounds and processes for the preparation of tapentadol and related compounds | MAPI PHARMA LTD. (IL) | 2013-04-02 | — | — | US | disclosed |
| US-20120283463-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | MAPI PHARMA LIMITED (IL) | 2012-11-08 | — | — | US | disclosed |
| EP-2519100-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | Mapi Pharma Limited (IL) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011157390-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED 3-(1-AMINO-2-METHYLPENTANE-3-YL)PHENYL COMPOUNDS | Grünenthal GmbH (DE) | 2011-12-22 | — | — | WO | disclosed |
| US-20110306793-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2011-12-15 | — | — | US | disclosed |
| US-20110306793-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | GRUENENTHAL GMBH (DE) | 2011-12-15 | — | — | US | disclosed |
| WO-2011080756-A1 | PROCESS FOR THE PREPARATION OF 1-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVES | IND-SWIFT LABORATORIES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011080736-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | MAPI PHARMA HK LIMITED (CN) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160257640-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | CYP51A1, CYP3A4, NPEPPS | AOC3 3145/4885L3MBTL1 2005/4885TDP1 2658/4885 |
| US-20170233330-A1 | Process for the preparation of 3-[(1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl]-phenol | AGTR1, SAT1, TMT1A | AOC3 1089/4885L3MBTL1 2715/4885TDP1 796/4885 |
| US-20110306793-A1 | Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds | NPEPPS, PNMT, CYP3A4 | AOC3 934/4885L3MBTL1 3975/4885TDP1 2507/4885 |
| US-20140046074-A1 | Substituted n-pentanamide compounds, preparation method and the use thereof | PNMT, TPMT, HTR3A | AOC3 2358/4885L3MBTL1 4583/4885TDP1 1823/4885 |
| US-20120283463-A1 | INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS | PNMT, OPRK1, CYP2E1 | AOC3 1481/4885L3MBTL1 4570/4885TDP1 1354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.