Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21574677 | 0.74 | PKM (0.45) | MAOAELANEPKMMAPTALDH1A1 | |
| SCHEMBL21004377 | 0.73 | PKM (0.45) | MAOAELANEPKMMAPTALDH1A1 | |
| SCHEMBL20882009 | 0.72 | IDO1 (0.44) | ALDH1A1KDM4EARPOLBSMN1; SMN2 | |
| SCHEMBL21574741 | 0.68 | KDM1A (0.44) | PKMALDH1A1KDM4EPSMB5RORC | |
| SCHEMBL14871016 | 0.67 | KDM4E (0.52) | ALDH1A1KDM4EARMEN1KMT2A | |
| SCHEMBL24625607 | 0.67 | SOS1 (0.41) | ALDH1A1LMNAHTTTDP1 | |
| SCHEMBL10063315 | 0.66 | ELANE (0.48) | ELANEMAPTALDH1A1LMNAKDM4E | |
| SCHEMBL16632811 | 0.66 | RORC (0.36) | TLR8TLR7ALDH1A1KDM4EAR | |
| SCHEMBL21574658 | 0.65 | PKM (0.58) | PKMMAPTALDH1A1LMNAKDM4E | |
| SCHEMBL18856329 | 0.65 | PLA2G2A (0.48) | TLR8MAPTALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057951-B1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2019-11-20 | — | — | EP | disclosed |