Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21587423 | 0.84 | GPR27 (0.34) | LMNAMAPK1MAPTCASP1CASP7 | |
| SCHEMBL20619771 | 0.78 | CD44 (0.33) | LMNAGAAMAOAMAOB | |
| SCHEMBL18609035 | 0.74 | TSHR (0.36) | MAOAMAOBALDH1A1 | |
| SCHEMBL29320334 | 0.73 | LOXL2 (0.38) | KMT2A | |
| SCHEMBL23222675 | 0.71 | — | — | |
| SCHEMBL21729549 | 0.69 | SLC6A2 (0.33) | MAPK1ALDH1A1 | |
| SCHEMBL19311402 | 0.69 | TRPA1 (0.38) | MAPTKMT2AMAOAMAOBALDH1A1 | |
| SCHEMBL24633667 | 0.68 | KDM4E (0.35) | ALDH1A1 | |
| SCHEMBL7197694 | 0.67 | MAOA (0.55) | LMNAMAPK1KMT2AMAOAMAOB | |
| SCHEMBL23891581 | 0.67 | HTR7 (0.45) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412660-B1 | SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | EA PHARMA CO LTD (JP) | 2020-11-18 | — | — | EP | disclosed |
| EP-3578557-A1 | CHEMICAL PROCESS FOR PREPARING SPIROINDOLONES AND INTERMEDIATES THEREOF | Novartis AG (CH) | 2019-12-11 | — | — | EP | disclosed |