SCHEMBL21591476

SCHEMBL21591476

O=c1c(CCl)coc2cc(Br)c(F)cc12

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CYP11B1 P15538 4/20 0.37
▸ CYP11B2 P19099 4/20 0.37
▸ CYP19A1 P11511 2/20 0.37
▸ CYP17A1 P05093 1/20 0.37
▸ MAOB P27338 3/20 0.34
▸ KCNH2 Q12809 1/20 0.34
▸ ALDH1A1 P00352 3/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ ADORA2A P29274 1/20 0.32
▸ PTPN1 P18031 3/20 0.31
▸ TSHR P16473 1/20 0.31
▸ PDE10A Q9Y233 1/20 0.31
▸ SIGMAR1 Q99720 1/20 0.30
▸ MAOA P21397 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21591553 0.75 CYP11B1 (0.62) CYP11B1CYP11B2CYP19A1CYP17A1MAOB
SCHEMBL21591484 0.75 MAPT (0.44) CYP11B1CYP11B2CYP19A1CYP17A1MAOB
SCHEMBL21591512 0.72 ALDH1A1 (0.43) ALDH1A1
SCHEMBL21591531 0.71 ALDH1A1 (0.32) ALDH1A1HSD17B10TSHR
SCHEMBL31474235 0.69 FTO (0.47) CYP19A1MAOBMAOA
SCHEMBL17321027 0.68 ALOX15 (0.45) ALDH1A1HSD17B10RAB9APTPN1TSHR
SCHEMBL19180128 0.68 PTPN1 (0.59) MAOBPTPN1MAOA
SCHEMBL9075843 0.67 MAOB (0.71) CYP11B1CYP11B2CYP19A1CYP17A1MAOB
SCHEMBL32670314 0.67 MEN1 (0.46) ALDH1A1HSD17B10TSHR
SCHEMBL19180090 0.67 ALDH1A1 (0.42) ALDH1A1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12162863-B2 Modulators of stimulator of interferon genes (STING) Ryvu Therapeutics S.A. (PL) 2024-12-10 — — US disclosed
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2022-12-22 — — US disclosed
EP-3807264-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2021-04-21 — — EP disclosed
WO-2019238786-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) Ryvu Therapeutics S.A. (PL) 2019-12-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12162863-B2 Modulators of stimulator of interferon genes (STING) STING1, IRF3, CGAS CYP11B1 43/4885CYP11B2 50/4885CYP19A1 589/4885
US-20220402898-A1 MODULATORS OF STIMULATOR OF INTERFERON GENES (STING) STING1, IRF3, CGAS CYP11B1 43/4885CYP11B2 50/4885CYP19A1 589/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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