Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21593114 | 0.88 | NR1H2 (0.44) | NR1H2CYP3A4ESR2GPR119HTR6 | |
| SCHEMBL21593086 | 0.85 | NR1H2 (0.44) | NR1H2CYP3A4ESR2GPR119HTR6 | |
| SCHEMBL21593172 | 0.80 | NR1H2 (0.43) | NR1H2CYP3A4ESR2GPR119HTR6 | |
| SCHEMBL25259649 | 0.79 | HTR6 (0.41) | NR1H2ESR2GPR119HTR6MAPT | |
| SCHEMBL23762168 | 0.77 | ACHE (0.39) | NR1H2CYP3A4HTR6ALDH1A1HPGD | |
| SCHEMBL21593084 | 0.76 | NR1H2 (0.42) | NR1H2ESR2GPR119HTR6KIT | |
| SCHEMBL21593208 | 0.76 | NR1H2 (0.56) | NR1H2CYP3A4ESR2MAPT | |
| SCHEMBL23646517 | 0.74 | NR1H2 (0.62) | NR1H2CYP3A4ESR2GPR119CHRM4 | |
| SCHEMBL21611514 | 0.74 | NR1H2 (0.53) | NR1H2CYP3A4ESR2GPR119CHRM4 | |
| SCHEMBL28970123 | 0.73 | GPR119 (0.38) | CYP3A4GPR119HTR6KITMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-08-19 | — | — | US | disclosed |
| WO-2019238628-A1 | AZAINDOLE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2019-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253568-A1 | AZAINDOLE DERIVATIVES AS RHO-KINASE INHIBITORS | ROCK1, ROCK2, RHOA | NR1H2 1422/4885CYP3A4 1670/4885ESR2 3940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.