Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 8/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL498131 | 0.84 | KDM4E (0.47) | KDM4ERECQLALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL4545012 | 0.83 | ALDH1A1 (0.45) | KDM4ERECQLALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL12589682 | 0.81 | RARB (0.50) | KDM4EALDH1A1SMN1; SMN2APPTSHR | |
| SCHEMBL8339774 | 0.79 | MAPT (0.52) | KDM4ERECQLL3MBTL1MAPTRAB9A | |
| SCHEMBL17500202 | 0.79 | KDM4E (0.56) | KDM4ERECQLALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL8943717 | 0.79 | L3MBTL1 (0.49) | KDM4ERECQLALDH1A1L3MBTL1APP | |
| SCHEMBL4745147 | 0.78 | CA1 (0.50) | KDM4EALDH1A1SMN1; SMN2APPADRA2A | |
| SCHEMBL19958268 | 0.78 | APP (0.62) | KDM4ERECQLALDH1A1APPMAPT | |
| SCHEMBL12659398 | 0.78 | L3MBTL1 (0.48) | KDM4ERECQLL3MBTL1MAPTTSHR | |
| SCHEMBL20251336 | 0.78 | DRD2 (0.46) | KDM4ERECQLL3MBTL1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |