Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PRNP | P04156 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160994 | 0.95 | HPGD (0.51) | HPGDLMNAALDH1A1PRNPRECQL | |
| Hydrochloric Acid SCHEMBL5725652 | 0.94 | HPGD (0.50) | HPGDLMNAALDH1A1PRNPRECQL | |
| SCHEMBL2412998 | 0.92 | HPGD (0.50) | HPGDLMNAALDH1A1PRNPRECQL | |
| Hydrochloric Acid SCHEMBL2410455 | 0.90 | HPGD (0.49) | HPGDLMNAALDH1A1PRNPRECQL | |
| SCHEMBL27621806 | 0.86 | HPGD (0.55) | HPGDLMNAALDH1A1PRNPRECQL | |
| SCHEMBL2162982 | 0.86 | HPGD (0.55) | HPGDLMNAALDH1A1PRNPRECQL | |
| SCHEMBL7211528 | 0.84 | HPGD (0.57) | HPGDLMNAALDH1A1PRNPRECQL | |
| SCHEMBL6981207 | 0.84 | HPGD (0.57) | HPGDLMNAALDH1A1PRNPRECQL | |
| SCHEMBL2162296 | 0.84 | HPGD (0.52) | HPGDLMNAALDH1A1PRNPRECQL | |
| SCHEMBL7211399 | 0.84 | HPGD (0.54) | HPGDLMNAALDH1A1PRNPRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2528908-B1 | THERAPEUTIC AGENTS FOR TREATMENT OF OCULAR HYPERTENSION | ALLERGAN INC (US) | 2019-03-13 | — | — | EP | disclosed |
| US-9090584-B2 | Therapeutic agents for treatment of ocular hypertension | ALLERGAN, INC. (US) | 2015-07-28 | — | — | US | disclosed |
| EP-2528908-A1 | THERAPEUTIC AGENTS FOR TREATMENT OF OCULAR HYPERTENSION | Allergan, Inc. (US) | 2012-12-05 | — | — | EP | disclosed |
| US-8198318-B2 | Therapeutic amides | ALLERGEN, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-8198318-B2 | Therapeutic amides | ALLERGEN, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| WO-2011094231-A1 | THERAPEUTIC AGENTS FOR TREATMENT OF OCULAR HYPERTENSION | ALLERGAN, INC. (US) | 2011-08-04 | — | — | WO | disclosed |
| US-20110184055-A1 | THERAPEUTIC AGENTS FOR TREATMENT OF OCULAR HYPERTENSION | ALLERGAN, INC. (US) | 2011-07-28 | — | — | US | disclosed |
| US-7985767-B2 | Glaucoma or ocular hypertension; selective prostaglandin EP2 agonists; carboxy-functional amides or sulfonamide and carboxy bioisosteres thereof; 5-(-3-(N-(4-(1-hydroxyhexyl)phenyl)acetamido)butyl)thiophene-2-carboxylic acid for example | ALLERGAN, INC. (US) | 2011-07-26 | — | — | US | disclosed |
| US-20090239858-A1 | THERAPEUTIC AMIDES | ALLERGAN, INC. (US) | 2009-09-24 | — | — | US | disclosed |
| US-20090239858-A1 | THERAPEUTIC AMIDES | ALLERGAN, INC. (US) | 2009-09-24 | — | — | US | disclosed |
| US-20080119539-A1 | THERAPEUTIC AMIDES | ALLERGAN, INC. | 2008-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119539-A1 | THERAPEUTIC AMIDES | GOT2, GOT1, ARG2 | HPGD 233/4885LMNA 3086/4885ALDH1A1 357/4885 |
| US-20090239858-A1 | THERAPEUTIC AMIDES | ACER2, SLC10A1, ASAH2 | HPGD 702/4885LMNA 2912/4885ALDH1A1 1121/4885 |
| US-20110184055-A1 | THERAPEUTIC AGENTS FOR TREATMENT OF OCULAR HYPERTENSION | PTGIR, PTGIS, AGTR2 | HPGD 98/4885LMNA 3581/4885ALDH1A1 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.