Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.50 |
| ▸ | GLS | O94925 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL726679 | 0.75 | ELANE (0.60) | ELANEGLSTAAR1UBE2NKDM4E | |
| SCHEMBL1514915 | 0.75 | ELANE (0.60) | ELANEGLSTAAR1UBE2NKDM4E | |
| SCHEMBL2589646 | 0.74 | ELANE (0.59) | ELANEGLSTAAR1UBE2NLMNA | |
| SCHEMBL21619644 | 0.73 | ELANE (0.48) | ELANEGLSTAAR1UBE2NKDM4E | |
| SCHEMBL27342474 | 0.71 | ELANE (0.56) | ELANEGLSTAAR1UBE2NKDM4E | |
| SCHEMBL21616365 | 0.70 | ELANE (0.51) | ELANEGLSTAAR1UBE2NCYP11B1 | |
| SCHEMBL18463756 | 0.70 | GLS (0.50) | ELANEGLSTAAR1UBE2NKDM4E | |
| SCHEMBL14193572 | 0.69 | ELANE (0.54) | ELANEGLSTAAR1UBE2NF2 | |
| SCHEMBL8216089 | 0.68 | ELANE (0.52) | ELANEGLSTAAR1UBE2NCYP11B1 | |
| SCHEMBL27891168 | 0.68 | ELANE (0.52) | ELANEGLSTAAR1UBE2NKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020011922-A1 | PHOTOINITIATOR COMPOUNDS | FUNDACIÓ INSTITUT CATALÀ D'INVESTIGACIÓ QUÍMICA (ICIQ) (ES) | 2020-01-16 | — | — | WO | disclosed |