SCHEMBL21628787

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL21628778	0.93	SMPD1 (0.54)	OPRM1OPRK1SMPD1HDAC1HDAC6
	SCHEMBL21628860	0.92	SMPD1 (0.58)	OPRM1OPRK1SMPD1S1PR1S1PR3
	SCHEMBL21628733	0.91	SMPD1 (0.60)	SMPD1S1PR1S1PR3
	SCHEMBL21628794	0.90	PLK1 (0.58)	OPRM1OPRK1SENP8SENP7SENP6
	SCHEMBL21628403	0.90	OPRM1 (0.52)	OPRM1OPRK1SMPD1HDAC1HDAC6
	SCHEMBL21628848	0.86	KMT2A (0.45)	SENP8SENP7SENP6S1PR1S1PR3
	SCHEMBL21628691	0.86	LMNA (0.54)	S1PR1S1PR3PTGER4PTGER2RAB9A
	SCHEMBL21628476	0.85	OPRK1 (0.53)	OPRM1OPRK1SENP8SENP7SENP6
	SCHEMBL21628451	0.83	HDAC1 (0.56)	OPRM1OPRK1HDAC1HDAC6
	SCHEMBL21628915	0.82	PLK1 (0.60)	HDAC1HDAC6PLK1POLBCTDSP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.