Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 4/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 5/20 | 0.37 |
| ▸ | TEK | Q02763 | 5/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16835258 | 0.83 | GRM5 (0.50) | PARP1PDK2BCAT2CSNK1A1TYRO3 | |
| SCHEMBL31329756 | 0.82 | CHRNB2 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4JAK2 | |
| SCHEMBL29134476 | 0.81 | KEAP1 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4JAK2 | |
| SCHEMBL16654579 | 0.81 | BCAT2 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4JAK2 | |
| SCHEMBL25420785 | 0.80 | BTK (0.39) | SYKCCNCCDK8JAK2CYP46A1 | |
| SCHEMBL23648683 | 0.80 | IKBKB (0.40) | CCNCCDK8CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7098623 | 0.80 | IKBKB (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4JAK2 | |
| SCHEMBL21629920 | 0.80 | CCNC (0.56) | CCNCCDK8PARP1PDK2BCAT2 | |
| Hydrochloric Acid SCHEMBL30692651 | 0.79 | BCAT2 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4JAK2 | |
| SCHEMBL21629999 | 0.76 | PDK2 (0.50) | SYKCCNCCDK8PARP1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200031801-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | GILEAD SCIENCES, INC. | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031801-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | SDHA, SLC10A1, CYP11B2 | SYK 3741/4885CCNC 669/4885CDK8 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.