SCHEMBL2163265

SCHEMBL2163265

[CH2]Oc1ccc(CN)cc1

nearest known ligand 0.56

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ST14 Q9Y5Y6 3/20 0.56
HRH3 Q9Y5N1 1/20 0.50
LOXL2 Q9Y4K0 3/20 0.48
MAOB P27338 8/20 0.47
ABAT P80404 1/20 0.46
KEAP1 Q14145 1/20 0.45
NFE2L2 Q16236 1/20 0.45
TAAR1 Q96RJ0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8757996 0.80 TAAR1 (0.61) MAOBTAAR1
SCHEMBL4209153 0.78 ST14 (0.85) ST14HRH3LOXL2MAOBABAT
SCHEMBL15828 0.76 HRH3 (0.79) ST14HRH3LOXL2ABATTAAR1
SCHEMBL4951818 0.74 MAOB (0.73) ST14MAOBTAAR1
SCHEMBL14459969 0.74 MAOB (0.57) ST14HRH3LOXL2MAOBKEAP1
SCHEMBL1846480 0.74 ALDH1A1 (0.43) ST14
SCHEMBL17801433 0.74 HRH3 (0.39) ST14HRH3
SCHEMBL970450 0.74 SMN1; SMN2 (0.45) TAAR1
SCHEMBL7973439 0.74 KEAP1 (0.67) ST14HRH3MAOBKEAP1NFE2L2
SCHEMBL29234304 0.74 ST14 (0.62) ST14HRH3LOXL2MAOBABAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101687909-B Composition for preventing or treating lung disease NISSHIN PHARMA INC 2013-12-18 CN disclosed
US-20110212899-A1 Corneal Neuritogenesis Promoter Containing Pacap and Its Derivative ILS INC. (JP) 2011-09-01 US disclosed
EP-1571155-B1 PEPTIDES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME ILS INC (JP) 2011-08-24 EP disclosed
US-20110183925-A1 ANTI-INFLAMMATORY PEPTIDE NISSHIN PHARMA INC. (JP) 2011-07-28 US disclosed
US-20100190723-A1 PREVENTIVE OR THERAPEUTIC COMPOSITION FOR LIVER DISEASE NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY (JP) 2010-07-29 US disclosed
CN-101687909-A Composition for preventing or treating lung disease NISSHIN PHARMA INC 2010-03-31 CN disclosed
EP-2151451-A1 COMPOSITION FOR PREVENTING OR TREATING LUNG DISEASE Nisshin Pharma Inc. (JP) 2010-02-10 EP disclosed
US-7332473-B2 Peptides and medicinal compositions containing the same ITOHAM FOODS INC. (JP) 2008-02-19 US disclosed
EP-1752158-A1 CORNEAL NEURITOGENESIS PROMOTER CONTAINING PACAP AND ITS DERIVATIVE Senju Pharmaceutical Co., Ltd. (JP) 2007-02-14 EP disclosed
US-20060276384-A1 Peptides and medicinal compositions containing the same ITOHAM FOODS INC. (JP) 2006-12-07 US disclosed
EP-0343248-B1 NOVEL POLYPEPTIDE AND METHOD FOR PREPARING THE SAME SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) 1993-04-21 EP disclosed
EP-0298474-B1 NOVEL CALCITONIN DERIVATIVE AND SALT THEREOF MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1992-11-19 EP disclosed
US-5068314-A Cyclic polypeptides useful for removal of endotoxins and bactericides SEIKAGAKU KOGYO CO. LTD. (JP) 1991-11-26 US disclosed
US-5010174-A Bone disorders, controlling calcium concentration in blood MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1991-04-23 US disclosed
EP-0370165-A2 Novel calcitonin derivative and salt thereof MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1990-05-30 EP disclosed
EP-0343248-A1 NOVEL POLYPEPTIDE AND METHOD FOR PREPARING THE SAME SEIKAGAKU KOGYO KABUSHIKI KAISHA (JP) 1989-11-29 EP disclosed
WO-1989001492-A1 NOVEL POLYPEPTIDE AND METHOD FOR PREPARING THE SAME SEIKAGAKU KOGYO CO. LTD. (JP) 1989-02-23 WO disclosed
EP-0298474-A2 Novel calcitonin derivative and salt thereof MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1989-01-11 EP disclosed
US-4525304-A Process for preparing oxazolinoazetidinones ELI LILLY AND COMPANY (US) 1985-06-25 US disclosed
EP-0109817-A2 Process for preparing oxazolinoazetidinones ELI LILLY AND COMPANY (US) 1984-05-30 EP disclosed