Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | APAF1 | O14727 | 2/20 | 0.43 |
| ▸ | TDP2 | O95551 | 2/20 | 0.43 |
| ▸ | NSD2 | O96028 | 2/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11208493 | 0.83 | NPSR1 (0.66) | HTTL3MBTL1NPSR1LMNAMAPT | |
| SCHEMBL2724212 | 0.72 | ALDH1A1 (0.54) | HTTL3MBTL1NPSR1MAPTKDM4E | |
| SCHEMBL25835313 | 0.70 | ALDH1A1 (0.47) | HTTL3MBTL1MAPTKDM4EAPAF1 | |
| SCHEMBL12822665 | 0.69 | POLB (0.51) | HTTL3MBTL1NPSR1LMNAMAPT | |
| SCHEMBL25835259 | 0.69 | POLB (0.51) | HTTL3MBTL1NPSR1LMNAMAPT | |
| SCHEMBL2956347 | 0.69 | ALDH1A1 (0.50) | HTTL3MBTL1NPSR1MAPTKDM4E | |
| SCHEMBL8624780 | 0.69 | CRBN (0.43) | HTTL3MBTL1NPSR1LMNAMAPT | |
| SCHEMBL17386423 | 0.68 | HTT (0.43) | HTTL3MBTL1NPSR1LMNAMAPT | |
| SCHEMBL7760631 | 0.66 | MEN1 (0.47) | HTTL3MBTL1NPSR1LMNAMAPT | |
| SCHEMBL28357232 | 0.66 | MAPT (0.44) | HTTL3MBTL1NPSR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240041849-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL OR MITOCHONDRIAL DISEASES | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2024-02-08 | — | — | US | disclosed |
| US-11771685-B2 | Compounds for the treatment of neurological or mitochondrial diseases | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2023-10-03 | — | — | US | disclosed |
| US-20220125774-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL OR MITOCHONDRIAL DISEASES | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2022-04-28 | — | — | US | disclosed |
| EP-3829560-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL OR MITOCHONDRIAL DISEASES | Musc Foundation for Research Development (US) | 2021-06-09 | — | — | EP | disclosed |
| CN-112770735-A | Compounds for the treatment of neurological or mitochondrial diseases | MUSC研究发展基金会 | 2021-05-07 | — | — | CN | disclosed |
| WO-2020028222-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL OR MITOCHONDRIAL DISEASES | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT (US) | 2020-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240041849-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL OR MITOCHONDRIAL DISEASES | MT-ND2, MT-ND1, NLN | HTT 225/4885L3MBTL1 1854/4885NPSR1 3346/4885 |
| US-11771685-B2 | Compounds for the treatment of neurological or mitochondrial diseases | MT-ND2, MT-ND1, NLN | HTT 225/4885L3MBTL1 1854/4885NPSR1 3346/4885 |
| US-20220125774-A1 | COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL OR MITOCHONDRIAL DISEASES | MT-ND2, MT-ND1, NLN | HTT 225/4885L3MBTL1 1854/4885NPSR1 3346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.